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Role of surrogate markers of atherosclerosis in clinical and subclinical thyroidism.
MedLine Citation:
PMID:  22505888     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Background. Data on the relationship between homocysteine, plasminogen activator inhibitor 1, hs-CRP, fibrinogen, and carotid intima media thickness (CA-IMT) is plenty but contradicting and the majority of the studies investigated this issue in only specific thyroidism groups. The aim of this paper was to investigate these relations in patients with subclinical and clinical hypo- and hyperthyroidism. Methods. In this cross-sectional study, 16 patients from each thyroidism group and 20 healthy cases were enrolled. Fibrinogen levels and plasminogen activator inhibitor 1 (PAI-1) activity were assessed. CA-IMT was determined by gray-scale high-resolution color Doppler ultrasound. Results. Serum homocysteine levels were higher in hypothyroidic patients compared to the control (P = 0.003). Fibrinogen levels were higher in patients with subclinical hypothyroidism compared to other groups (P < 0.05). There was no difference between groups regarding PAI-1. Whereas total cholesterol, homocysteine, and LDL were correlated with CAIMT, hs-CRP, PAI-1, and fibrinogen were not. In the clinical hypothyroidism group, the correlation of homocysteine with CA-IMT was derived from the correlation between CA-IMT and homocysteine. Conclusions. Homocysteine and fibrinogen levels are higher in patients with clinical and subclinical hypothyroidism, respectively. Homocysteine level is associated with CA-IMTonly in patients with clinical hypothyroidism.
Authors:
Mehmet Gunduz; Ercan Gunduz; Fatih Kircelli; Nazan Okur; Mesut Ozkaya
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Publication Detail:
Type:  Journal Article     Date:  2012-02-23
Journal Detail:
Title:  International journal of endocrinology     Volume:  2012     ISSN:  1687-8345     ISO Abbreviation:  Int J Endocrinol     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101516376     Medline TA:  Int J Endocrinol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  109797     Citation Subset:  -    
Affiliation:
Department of Internal Medicine, Kahramanmaras University, 46000 Kahramanmaras, Turkey.
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