Document Detail

Role of the supplementary motor area in motor deficit following medial frontal lobe surgery.
MedLine Citation:
PMID:  11552019     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Patients undergoing surgical resection of medial frontal lesions may present a transient postoperative deficit that remains largely unpredictable. The authors studied the role of the supplementary motor area (SMA) in the occurrence of this deficit using fMRI. METHODS: Twenty-three patients underwent a preoperative fMRI before resection of medial frontal lesions. Tasks included self-paced flexion/extension of the left and right hand, successively. Preoperative fMRI data were compared with postoperative MRI data and with neurologic outcome. RESULTS: Following surgery, 11 patients had a motor deficit from which all patients recovered within a few weeks or months. The deficit was similar across patients, consisting of a global reduction in spontaneous movements contralateral to the operated side with variable severity. SMA activation was observed in all patients. The deficit was observed when the area activated in the posterior part of the SMA (SMA proper) was resected. CONCLUSIONS: fMRI is able to identify the area at risk in the SMA proper whose resection is highly related to the occurrence of the motor deficit. The clinical characteristics of this deficit support the role of the SMA proper in the initiation and execution of the movement.
A Krainik; S Lehéricy; H Duffau; M Vlaicu; F Poupon; L Capelle; P Cornu; S Clemenceau; M Sahel; C A Valery; A L Boch; J F Mangin; D L Bihan; C Marsault
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  57     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  2001 Sep 
Date Detail:
Created Date:  2001-09-11     Completed Date:  2001-10-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  871-8     Citation Subset:  AIM; IM    
Department of Neuroradiology, Hôpital de la Salpêtrière, Paris, France.
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MeSH Terms
Brain Neoplasms / surgery
Frontal Lobe / physiopathology,  surgery
Magnetic Resonance Imaging
Middle Aged
Motor Cortex / physiopathology*,  surgery
Motor Skills Disorders* / physiopathology
Postoperative Complications*
Retrospective Studies

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