| Role of superoxide anion in pancreatic islet blood flow regulation in anesthetized rats. | |
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MedLine Citation:
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PMID: 12505534 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of the investigation was to study the influence of the superoxide anion on pancreatic islet blood flow in rats. For this purpose, blood flow measurements were conducted with a microsphere technique 10 min after intravenous administration of different doses of superoxide dismutase (5, 15, 50, 100 or 1000 kU/kg body weight). In separate experiments, diethyldithiodicarbamate, an inhibitor of endogenous superoxide dismutase, was given to nontreated control rats or to rats subjected to a bilateral abdominal vagotomy before the injection. Only the highest dose of superoxide dismutase increased both whole pancreatic and islet blood flow. A 50% augmentation of fractional islet blood flow was seen. Administration of diethyldithiocarbamate induced marked hyperglycemia, which was partly prevented by vagotomy. Diethyldithiocarbamate decreased the whole pancreatic blood flow, while islet blood flow was maintained in both control and vagotomized rats. Consequently, a pronounced increase in fractional islet blood flow was noted in both these groups. We conclude that administration of superoxide dismutase and its inhibitor diethyldithiocarbamate influences pancreatic blood perfusion. In particular, superoxide dismutase causes a general increase in the whole pancreatic and islet blood flow, and an augmented fractional islet blood flow, presumably by a decrease in the local concentration of O(2)(z.rad;-), leading to increased concentration of NO. Diethyldithiocarbamate, on the other hand, by increasing the levels of O(2)(z.rad;-), decreases the whole pancreatic blood flow, whereas islet blood flow remains unaffected. |
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Authors:
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Annika M Svensson; Stellan Sandler; Leif Jansson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: European journal of pharmacology Volume: 459 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2003 Jan |
Date Detail:
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Created Date: 2002-12-30 Completed Date: 2003-04-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 59-64 Citation Subset: IM |
Affiliation:
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Department of Medical Cell Biology, Biomedical Centre, P.O. Box 571, S-751 23, Uppsala, Sweden. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia Animals Chelating Agents / pharmacology Ditiocarb / pharmacology Dose-Response Relationship, Drug Injections, Intravenous Islets of Langerhans / blood supply*, innervation Male Rats Rats, Sprague-Dawley Regional Blood Flow / drug effects Superoxide Dismutase / antagonists & inhibitors, metabolism, pharmacology Superoxides / metabolism* Vagotomy |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 11062-77-4/Superoxides; 147-84-2/Ditiocarb; EC 1.15.1.1/Superoxide Dismutase |
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