| Role of superoxide, NO and oxygen in the regulation of energy metabolism and suppression of senile diseases. | |
| | |
MedLine Citation:
|
PMID: 10656528 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Although nitric oxide (NO) rapidly reacts with molecular oxygen under air atmospheric conditions, thereby losing its biological functions, the lifetime of this gaseous radical increases under physiologically low intracellular oxygen tensions. To understand the pathophysiological roles of NO and related molecules in aerobic life, we analyzed the effect of oxygen tensions on the NO-dependent processes in resistance arteries, isolated mitochondria, intact cells and enteric bacteria. Kinetic analysis revealed that NO enhanced the generation of cGMP and induced vasorelaxation of resistance arteries more potently under physiologically low oxygen tensions than under hyperbaric conditions. NO reversibly inhibited the respiration of isolated mitochondria, intact cells and Escherichia coli; the inhibitory effect was more marked under hypoxic conditions than under hyperbaric conditions. Kinetic analysis revealed that NO has pivotal action to increase arterial supply of molecular oxygen for the generation of ATP in peripheral tissues and to suppress energy production in mitochondria and cells in an oxygen-dependent manner. These functions of NO are enhanced by decreasing oxygen tension in situ and suppressed by locally generated superoxide radicals. Thus, cross-talk of NO, superoxide and molecular oxygen constitutes a supersystem by which the energy metabolism in cells and tissues is beautifully regulated in a site-specific manner depending on the relative concentrations of these three radical species. |
| | |
Authors:
|
M Inoue; M Nishikawa; E Kasahara; E Sato |
Related Documents
:
|
8549998 - An expert system applied to the physiological analysis of early stage of beer fermentat... 17482568 - Relationship between reactive oxygen species and heme metabolism during the differentia... 7781988 - Kinetics of substrate oxidation by whole cells and cell membranes of helicobacter pylori. 21866308 - The alterations in hepatic microcirculation and kupffer cell activity after biliary dra... 17160018 - Pbk/topk promotes tumour cell proliferation through p38 mapk activity and regulation of... 22292048 - Selective induction of cell death in melanoma cell lines through targeting of mcl-1 and... |
Publication Detail:
|
Type: Journal Article; Review |
Journal Detail:
|
Title: Mechanisms of ageing and development Volume: 111 ISSN: 0047-6374 ISO Abbreviation: Mech. Ageing Dev. Publication Date: 1999 Nov |
Date Detail:
|
Created Date: 2000-02-18 Completed Date: 2000-02-18 Revised Date: 2005-11-16 |
Medline Journal Info:
|
Nlm Unique ID: 0347227 Medline TA: Mech Ageing Dev Country: IRELAND |
Other Details:
|
Languages: eng Pagination: 89-95 Citation Subset: IM |
Affiliation:
|
Department of Biochemistry, Osaka City University Medical School, Osaka, Japan. inoue@med.osaka-cu.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Aging / physiology* Animals Arteries / physiology Energy Metabolism / physiology* Escherichia coli / physiology Humans Mitochondria / physiology Nitric Oxide / physiology* Oxygen / physiology* Superoxides / metabolism* |
| Chemical | |
Reg. No./Substance:
|
10102-43-9/Nitric Oxide; 11062-77-4/Superoxides; 7782-44-7/Oxygen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Approaches to anti-aging intervention: the promises and the uncertainties.
Next Document: Dietary modulation of prostanoid synthesis in the aging process: role of cyclooxygenase-2.