Document Detail


Role of standardized and study-specific human brain diffusion tensor templates in inter-subject spatial normalization.
MedLine Citation:
PMID:  23034880     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: To investigate the effect of standardized and study-specific human brain diffusion tensor templates on the accuracy of spatial normalization, without ignoring the important roles of data quality and registration algorithm effectiveness.
MATERIALS AND METHODS: Two groups of diffusion tensor imaging (DTI) datasets, with and without visible artifacts, were normalized to two standardized diffusion tensor templates (IIT2, ICBM81) as well as study-specific templates, using three registration approaches. The accuracy of inter-subject spatial normalization was compared across templates, using the most effective registration technique for each template and group of data.
RESULTS: It was demonstrated that, for DTI data with visible artifacts, the study-specific template resulted in significantly higher spatial normalization accuracy than standardized templates. However, for data without visible artifacts, the study-specific template and the standardized template of higher quality (IIT2) resulted in similar normalization accuracy.
CONCLUSION: For DTI data with visible artifacts, a carefully constructed study-specific template may achieve higher normalization accuracy than that of standardized templates. However, as DTI data quality improves, a high-quality standardized template may be more advantageous than a study-specific template, because in addition to high normalization accuracy, it provides a standard reference across studies, as well as automated localization/segmentation when accompanied by anatomical labels.
Authors:
Shengwei Zhang; Konstantinos Arfanakis
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-10-03
Journal Detail:
Title:  Journal of magnetic resonance imaging : JMRI     Volume:  37     ISSN:  1522-2586     ISO Abbreviation:  J Magn Reson Imaging     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-28     Completed Date:  2013-08-07     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9105850     Medline TA:  J Magn Reson Imaging     Country:  United States    
Other Details:
Languages:  eng     Pagination:  372-81     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
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MeSH Terms
Descriptor/Qualifier:
Adult
Brain / anatomy & histology*
Diffusion Magnetic Resonance Imaging / methods*,  standards*
Female
Humans
Image Interpretation, Computer-Assisted / methods*,  standards*
Male
Reference Values
Reproducibility of Results
Sensitivity and Specificity
United States
Young Adult
Grant Support
ID/Acronym/Agency:
R21 EB006525/EB/NIBIB NIH HHS; R21 NS076827/NS/NINDS NIH HHS; R21EB006525/EB/NIBIB NIH HHS; R21NS076827/NS/NINDS NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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