Document Detail

Role of splenectomy in immune (idiopathic) thrombocytopenic purpura.
MedLine Citation:
PMID:  11913993     Owner:  NLM     Status:  MEDLINE    
Idiopathic thrombocytopenic purpura (ITP) is an immune disorder, which causes an acute or chronic thrombocytopenia, and may result in potentially life-threatening hemorrhage. Splenectomy is one of the treatment options that needs to be weighed in the treatment of ITP, particularly in cases that have shown response failure to medical modalities such as prednisone, i.v.Ig, or anti-D globulin therapy. Although most studies demonstrate good early response following splenectomy, the long-term outcome is less favorable. Furthermore, other negative factors, such as rendering the patient ineligible for anti-D globulin or oral tolerance therapy and vulnerable to possible life-threatening sepsis, must be weighed prior to splenectomy.
W R Bell
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Blood reviews     Volume:  16     ISSN:  0268-960X     ISO Abbreviation:  Blood Rev.     Publication Date:  2002 Mar 
Date Detail:
Created Date:  2002-03-26     Completed Date:  2002-08-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8708558     Medline TA:  Blood Rev     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  39-41     Citation Subset:  IM    
Copyright Information:
Copyright 2002, Elsevier Science Ltd. All rights reserved.
Department of Medicine, The Johns Hopkins University School of Medicine, The Johns Hopkins Medical Institutions, Baltimore, MD 21287-4928, USA.
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MeSH Terms
Disease Management
Purpura, Thrombocytopenic, Idiopathic / surgery*
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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