Document Detail


Role of specific dietary amino acids in clinical conditions.
MedLine Citation:
PMID:  23107525     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
In a variety of chronic and acute disease states, alterations in protein synthesis, breakdown and protein turnover rates occur that are related to the loss of body protein and skeletal muscle wasting. A key observation is the stimulation of protein breakdown in muscle and the stimulation of protein synthesis in the splanchnic area; mainly liver. An altered splanchnic extraction of amino acids as well as an anabolic resistance to dietary protein, related to stress, disuse and aging play a key role in the pathogenesis of muscle wasting in these conditions. To overcome these factors, specific dietary protein and amino acid diets have been introduced. The main focus of these diets is the quantity and quality of dietary proteins and whether a balanced mixture or solely dietary essential amino acids are required with or without higher intake levels of specific amino acids. Specifically in cancer patients, stimulated muscle protein synthesis has been obtained by increasing the amount of protein in a meal and by providing additional leucine. Also in other chronic diseases such as chronic obstructive pulmonary disease and cystic fibrosis, meals with specific dietary proteins and specific combinations of dietary essential amino acids are able to stimulate anabolism. In acute diseases, a special role for the amino acid arginine and its precursor citrulline as anabolic drivers has been observed. Thus, there is growing evidence that modifying the dietary amino acid composition of a meal will positively influence the net balance between muscle protein synthesis and breakdown, leading to muscle protein anabolism in a variety of chronic and acute disease states. Specific amino acids with anabolic potential are leucine, arginine and citrulline.
Authors:
Renate Jonker; Mariëlle P K J Engelen; Nicolaas E P Deutz
Related Documents :
2118165 - Biochemical and immunological comparison of lipopolysaccharides from bordetella species.
9095555 - Structural study of an exocellular polysaccharide of bacillus circulans.
9275285 - Structure of the acid-labile galactosyl phosphate-containing o-antigen of the bacterium...
3752995 - Lipoteichoic acids in lactobacillus strains that colonize the mouse gastric epithelium.
16656425 - Fatty acid accumulation in maturing flaxseeds as influenced by environment.
23107535 - Ileal and faecal protein digestibility measurement in humans and other non-ruminants - ...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The British journal of nutrition     Volume:  108 Suppl 2     ISSN:  1475-2662     ISO Abbreviation:  Br. J. Nutr.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-10-30     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372547     Medline TA:  Br J Nutr     Country:  England    
Other Details:
Languages:  eng     Pagination:  S139-48     Citation Subset:  IM    
Affiliation:
Department of Health & Kinesiology, Texas A&M University, Suite #210, 1700 Research Parkway, College Station, Texas, 77843-4253, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The role of high-protein diets in body weight management and health.
Next Document:  Food proteins as a source of bioactive peptides with diverse functions.