Document Detail


Role of soluble epoxide hydrolase phosphatase activity in the metabolism of lysophosphatidic acids.
MedLine Citation:
PMID:  22387545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The EPXH2 gene encodes for the soluble epoxide hydrolase (sEH), which has two distinct enzyme activities: epoxide hydrolase (Cterm-EH) and phosphatase (Nterm-phos). The Cterm-EH is involved in the metabolism of epoxides from arachidonic acid and other unsaturated fatty acids, endogenous chemical mediators that play important roles in blood pressure regulation, cell growth, inflammation and pain. While recent findings suggested complementary biological roles for Nterm-phos, its mode of action is not well understood. Herein, we demonstrate that lysophosphatidic acids are excellent substrates for Nterm-phos. We also showed that sEH phosphatase activity represents a significant (20-60%) part of LPA cellular hydrolysis, especially in the cytosol. This possible role of sEH on LPA hydrolysis could explain some of the biology previously associated with the Nterm-phos. These findings also underline possible cellular mechanisms by which both activities of sEH (EH and phosphatase) may have complementary or opposite roles.
Authors:
Christophe Morisseau; Nils Helge Schebb; Hua Dong; Arzu Ulu; Pavel A Aronov; Bruce D Hammock
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-02-24
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  419     ISSN:  1090-2104     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-03-26     Completed Date:  2012-05-11     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  796-800     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Epoxide Hydrolases / chemistry,  genetics,  metabolism*
Humans
Lysophospholipids / metabolism*
Organophosphates / chemistry,  isolation & purification,  metabolism
Small Molecule Libraries
Solubility
Substrate Specificity
Grant Support
ID/Acronym/Agency:
ES02710/ES/NIEHS NIH HHS; P42 ES004699/ES/NIEHS NIH HHS; P42 ES004699-26/ES/NIEHS NIH HHS; P42 ES04699/ES/NIEHS NIH HHS; R01 ES002710/ES/NIEHS NIH HHS; R01 ES002710-32/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Lysophospholipids; 0/Organophosphates; 0/Small Molecule Libraries; EC 3.3.2.-/Epoxide Hydrolases; EC 3.3.2.10/EPHX2 protein, human
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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