Document Detail

Role of soluble and cell surface molecules in the pathogenesis of autoimmune skin diseases.
MedLine Citation:
PMID:  16466628     Owner:  NLM     Status:  MEDLINE    
The skin is one of the most commonly involved tissue in rheumatic autoimmune diseases. Different mechanisms are thought to be implicated in the pathogenesis of skin lesions. In genetically predisposed individuals, ultraviolet (UV) light can contribute to the induction of skin lesions via an inflammatory process. UV light promotes the release of cytokines by keratinocytes and the induction of adhesion molecules on the surface of epidermal cells initiating a cascade of inflammatory events and recruiting immunoinflammatory cells into the skin. In this review data regarding the expression of TNF-alpha in lesional skin tissue from subacute cutaneous lupus erythematosus patients and the role of interferons in the pathogenesis of skin manifestations of rheumatic autoimmune diseases are reported. In addition, an overview on the expression of cellular adhesion molecules in these diseases is provided.UV light can also induce apoptosis in keratinocytes. During this cell death several enzymes became activated. Among them, desoxyribonuclease (DNase) is an enzyme involved in degrading DNA during apoptosis. Data regarding the activity of DNAse in patients with cutaneous lupus erythematosus as a possible risk factor for the development of systemic disease are here reported.
M Drosera; F Facchetti; S Landolfo; M Mondini; F Nyberg; A Parodi; A Santoro; S Zampieri; A Doria
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Clinical and experimental rheumatology     Volume:  24     ISSN:  0392-856X     ISO Abbreviation:  Clin. Exp. Rheumatol.     Publication Date:    2006 Jan-Feb
Date Detail:
Created Date:  2006-02-09     Completed Date:  2006-06-15     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  8308521     Medline TA:  Clin Exp Rheumatol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  S7-13     Citation Subset:  IM    
Di.S.E.M. Section of Dermatology, University of Genoa, Genoa, Italy.
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MeSH Terms
Autoimmune Diseases / immunology*
Cell Adhesion Molecules / physiology*
Deoxyribonucleases / metabolism
Interferons / physiology
Lupus Erythematosus, Cutaneous / immunology
Skin Diseases / immunology*
Tumor Necrosis Factor-alpha / physiology*
Reg. No./Substance:
0/Cell Adhesion Molecules; 0/Tumor Necrosis Factor-alpha; 9008-11-1/Interferons; EC 3.1.-/Deoxyribonucleases

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