Document Detail

Role of sodium in dialysis.
MedLine Citation:
PMID:  15467499     Owner:  NLM     Status:  MEDLINE    
The total amount of sodium present in the body conditions the extracellular compartment volume. In advanced renal failure and in dialysis the sodium balance becomes positive and the extracellular volume inflates. This leads to hypertension and to direct cardiac and vascular changes that explain for a large part the excessive cardiovascular morbidity and mortality in dialysis patients. Controlling body sodium content and extracellular volume allows to reduce hypertension, cardiovascular changes and to improve dialysis patients survival. This can be achieved by reducing the sodium input (low sodium diet and reasonably low sodium dialysate) and/or by increasing sodium output (ultrafiltration by convection in hemodialysis or hemofiltration and osmotic drive in peritoneal dialysis). The intermittent nature of hemodialysis (and hemofiltration) conditions the saw-tooth volume fluctuations that drove to conceiving and implementing the concept of a dry weight, corresponding to normal extracellular volume and blood pressure.
B Charra; C Chazot; G Jean; J-M Hurot; J-C Terrat; T Vanel; C Lorriaux; C Vovan
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Minerva urologica e nefrologica = The Italian journal of urology and nephrology     Volume:  56     ISSN:  0393-2249     ISO Abbreviation:  Minerva Urol Nefrol     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2004-12-06     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  8503649     Medline TA:  Minerva Urol Nefrol     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  205-13     Citation Subset:  IM    
Center of Artificial Kidney, France.
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MeSH Terms
Blood Pressure
Kidney Failure, Chronic / metabolism*,  therapy*
Renal Dialysis*
Sodium / metabolism*,  physiology
Water-Electrolyte Imbalance / etiology,  metabolism
Reg. No./Substance:

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