Document Detail


Role of skeletal muscle sodium pumps in the adaptation to potassium deprivation.
MedLine Citation:
PMID:  8729690     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Skeletal muscle is specialized to lose K+ to the extracellular fluid during potassium deprivation which buffers the fall in plasma K+ concentration. While it remains to be determined whether K+ efflux from muscle is altered during K+ deprivation, active K+ uptake driven by sodium pumps is significantly depressed. The activity of sodium pumps in skeletal muscle does not increase during K+ depletion despite elevated intracellular Na+, a strong stimulus to increase activity in other cells. There is a decrease in the total pool size of sodium pump alpha beta heterodimers during potassium deprivation. The alpha 2 (not the alpha 1) sodium pump isoform is specifically decreased and beta 1 and/or beta 2 decreases in a muscle-fibre-dependent manner. The specific loss of K+ from skeletal muscle is probably a consequence of the fact that the alpha 2 isoform predominates in this tissue. In tissues such as heart, where alpha 2-type pumps are only a minor fraction of the sodium pumps, the activity of the ubiquitous alpha 1 isoform maintains intracellular Na+ and K+ at control levels, despite the fact that alpha 2 levels decrease by 50%. Analysis of the time course of change in alpha 2 mRNA vs. protein during K+ deprivation indicates that there is both a decrease in alpha 2 synthesis and an increase in alpha 2 degradation. The apparent time-lag during potassium deprivation between the early decreases in both surface alpha 2-type sodium pump number (assessed by 3H-ouabain binding) and intracellular K+, and the later decrease in total pool size of alpha 2, suggests the hypothesis that there may be an early internalization of alpha 2 sodium pumps to endosomal pools, followed by a degradation of these internalized pumps, contributing to the decrease in total alpha 2 pool size. The signals mediating this specific response to hypokalemia, and those mediating the restoration of muscle K+ stores remain to be determined.
Authors:
A A McDonough; C B Thompson
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  156     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-10-23     Completed Date:  1996-10-23     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  295-304     Citation Subset:  IM    
Affiliation:
Department of Physiology and Biophysics, University of Southern California School of Medicine, Los Angeles 90033, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Homeostasis / physiology
Humans
Muscle, Skeletal / metabolism*,  physiopathology*
Potassium Deficiency / physiopathology*
Sodium-Potassium-Exchanging ATPase / metabolism*
Chemical
Reg. No./Substance:
EC 3.6.3.9/Sodium-Potassium-Exchanging ATPase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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