Document Detail

Role of signal transduction and actin in G1 phase progression.
MedLine Citation:
PMID:  16197985     Owner:  NLM     Status:  MEDLINE    
Progression through the cell cycle of mammalian cells is dependent upon external factors such as growth- and ECM factors. These factors exert their effect predominantly during the G1 phase of the cell cycle. When cells are cultured in suspension or when growth factors are withdrawn from the medium, cells will stop cell cycle progression and enter a quiescent state. Cells will remain in this quiescent state until extracellular conditions change and cells are stimulated to re-enter the cell cycle. This stimulation is mediated by various signal transduction cascades such as the mitogen-activated protein kinase (MAPK) pathway and the phosphatidylinositol 3-kinase (PI3-kinase) pathway. In Chinese hamster ovary cells at least two serum-dependent points exist during G1 phase that lead to diffent cellular responses. The first point is located immediately after mitosis and is suggested to link with apoptosis. The second point is located in late G1 phase and probably corresponds with cellular differentiation. Signal transduction is mutually related to the cytoskeleton, especially the actin microfilament system. The actin microfilament system influences signal transduction and several signal transduction pathways influence the actin structure. Here we describe the role of the MAPK and PI3-kinase activities and of actin microfilaments in progression through the cell cycle and their role in the two G1 checkpoints.
Ang?lique van Opstal; Jose J M Bijvelt; Coert Margadant; Johannes Boonstra
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Publication Detail:
Type:  Journal Article     Date:  2005-09-27
Journal Detail:
Title:  Advances in enzyme regulation     Volume:  45     ISSN:  0065-2571     ISO Abbreviation:  Adv. Enzyme Regul.     Publication Date:  2005  
Date Detail:
Created Date:  2005-12-06     Completed Date:  2006-02-28     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0044263     Medline TA:  Adv Enzyme Regul     Country:  England    
Other Details:
Languages:  eng     Pagination:  186-200     Citation Subset:  IM    
Department of Molecular Cell Biology, Institute of Biomembranes, Utrecht University, Padualaan 8, 3584CH Utrecht, The Netherlands.
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MeSH Terms
1-Phosphatidylinositol 3-Kinase / physiology
Actins / physiology*
CHO Cells
Cyclin-Dependent Kinase Inhibitor Proteins / physiology
Extracellular Matrix / physiology
G1 Phase / physiology*
Growth Substances / physiology
MAP Kinase Signaling System / physiology
Mitogen-Activated Protein Kinase 1 / physiology
Signal Transduction / drug effects,  physiology*
Reg. No./Substance:
0/Actins; 0/Cyclin-Dependent Kinase Inhibitor Proteins; 0/Growth Substances; EC 3-Kinase; EC Protein Kinase 1

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