Document Detail


Role of serum high mobility group box 1 in hematological malignancies complicated with systemic inflammatory response syndrome and effect of recombinant thrombomodulin.
MedLine Citation:
PMID:  23339448     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT High mobility group box 1 (HMGB1) mediates inflammation. We investigated the role of serum HMGB1 in 54 patients with hematological malignancies with and without systemic inflammatory response syndrome (SIRS). There was no difference between group1 (complete remission of hematological disease: n = 13) and 2 (no remission:n = 16) in serum HMGB1 levels. However, those of group 3 (complicated with SIRS: n = 25) were significantly higher (vs. group 1: p < 0.001 and vs. group 2: p=0.008, respectively). Seventeen patients in group 3 also developed DIC and received recombinant human thrombomodulin (rhTM). Thirteen of those with SIRS improved and serum HMGB1 levels significantly decreased (p = 0.047). Seven patients in group 3 who died within 28 days of SIRS onset had significantly higher serum HMGB1 levels than the survivors (p = 0.016). The anti-HMGB1 properties of rhTM might be useful therapy if serum HMGB1 is associated with the development of SIRS in the presence of hematological malignancies.
Authors:
Yasuyuki Inoue; Tasuku Saito; Kohei Ogawa; Yuji Nishio; Shigeki Kosugi; Yoshinori Suzuki; Hirotaka Sakai; Masayuki Kato; Masatomo Takahashi; Ikuo Miura
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-23
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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