Document Detail

Role of serum amyloid P in skin graft survival and wound healing in burned patients receiving skin grafts.
MedLine Citation:
PMID:  20932823     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent studies in animal models suggest that serum amyloid P (SAP) can affect burn wound healing. However, the role of SAP in a clinical setting remains unknown.
METHODS: We enrolled 88 patients with third degree burn wounds. All the patients were candidates for auto-skin graft procedure using stamp skin graft. The complete graft healing time and the number of survived grafts were recorded. Serum SAP levels were assessed 1 day before operation.
RESULTS: There was no significant difference in SAP level between controls and patients. There were no significant differences noted among the patients with different burn surface area. However, when the patients in each group were stratified by SAP levels, the mean complete healing time of grafted wound and the mean numbers of survived skin grafts were significantly different. Spearman's analyses showed that the serum SAP levels negatively correlated with the complete wound healing time and mean numbers of survived skin grafts. Logistic regression analysis showed that the serum SAP levels and mean numbers of survived skin grafts were potent independent factors contributing to wound healing.
CONCLUSIONS: The results of this study suggest that the serum SAP levels may be an easy detected predictor for the healing of burn wounds.
Yi-ming Zhang; Ya-dong Fang; Yi-cheng Wang; Shao-liang Wang; Ze-yuan Lei; Xiao-wei Liu; Tong-chun Mao; Dong-li Fan
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Publication Detail:
Type:  Journal Article     Date:  2010-10-12
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  412     ISSN:  1873-3492     ISO Abbreviation:  Clin. Chim. Acta     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-20     Completed Date:  2011-03-24     Revised Date:  2013-07-23    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  227-9     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2010. Published by Elsevier B.V. All rights reserved.
Department of Plastic and Cosmetic Surgery, Xinqiao Hospital, Third Military Medical University, Xinqiao Road, Sha Ping Ba District, Chongqing 400037, People's Republic of China.
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MeSH Terms
Burns / immunology,  metabolism*,  physiopathology,  surgery*
Case-Control Studies
Graft Survival*
Serum Amyloid P-Component / metabolism*
Skin Transplantation*
Wound Healing*
Reg. No./Substance:
0/Serum Amyloid P-Component
Erratum In:
Clin Chim Acta. 2011 Mar 18;412(7-8):670

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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