Document Detail

Role for serial prenatal anti-Vel quantitative serologic monitoring with 2-ME serum treatment during pregnancy: case report.
MedLine Citation:
PMID:  20795312     Owner:  NLM     Status:  MEDLINE    
Anti-Vel is an uncommon antibody to a high-prevalence antigen. Its clinical significance and management in the prenatal setting are not well characterized. We present a case that demonstrates the utility of serial prenatal anti-Vel quantitative serologic monitoring with 2-ME serum treatment during pregnancy. The patient is a 23-year-old Hispanic woman with history of prior pregnancy and prior transfusion who was discovered to have an antibody to the high-prevalence Vel antigen in the first trimester (week 7) of her second pregnancy. Interval measurements of the serologic antibody titers were performed during the next 26 weeks. The untreated serum (IgM and IgG) titer increased from a baseline of 4 to 16 during that interval, while the 2-ME (presumed IgG component) titer remained stable at 4. Responding to ultrasound findings suspicious for fetal anemia, the child was delivered without complications at 34 weeks' gestation. At birth, the DAT was negative and there was no evidence of HDN. Placed in the context of other similar reports, this case demonstrates the importance of separately reporting the IgG fraction (after either DTT treatment or 2-ME treatment) from the untreated (IgM and IgG) fraction and the importance of correlating the treated serum titer with potential clinical significance.
W J Linz; J T Fueger; S Allen; S T Johnson
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Immunohematology / American Red Cross     Volume:  26     ISSN:  0894-203X     ISO Abbreviation:  Immunohematology     Publication Date:  2010  
Date Detail:
Created Date:  2010-08-27     Completed Date:  2010-10-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806387     Medline TA:  Immunohematology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-10     Citation Subset:  IM    
Scott and White Transfusion Service and Donor Center, Texas A&M UHSC, Temple TX 76508, USA.
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MeSH Terms
Anemia / blood,  genetics,  ultrasonography
Antibody Specificity
Blood Group Antigens / immunology*
Cesarean Section
Dithiothreitol / pharmacology
Erythroblastosis, Fetal / blood,  prevention & control*
Fetal Blood / immunology
Fetal Diseases / blood,  genetics,  ultrasonography
Immunoglobulin G / blood
Immunoglobulin M / blood
Infant, Newborn
Isoantibodies / blood*
Mercaptoethanol / pharmacology
Prenatal Care*
Serum / drug effects,  immunology
Surgical Procedures, Elective
Ultrasonography, Prenatal
Young Adult
Reg. No./Substance:
0/Blood Group Antigens; 0/Immunoglobulin G; 0/Immunoglobulin M; 0/Isoantibodies; 3483-12-3/Dithiothreitol; 60-24-2/Mercaptoethanol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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