Document Detail


Role of sentinel lymph node biopsy in high-risk ductal carcinoma in situ patients.
MedLine Citation:
PMID:  17618799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The role of sentinel lymph node biopsy (SLNB) for ductal carcinoma in situ (DCIS) is poorly defined. However, up to 20% of patients with DCIS will have invasive carcinoma; these patients require staging for axillary metastasis. The aim of this study was to identify patients with a core biopsy diagnosis of DCIS who may benefit from SLNB. METHODS: In a prospective study, we performed SLNB on patients with a preoperative diagnosis of >2.5 cm of high-grade DCIS or DCIS when mastectomy was indicated. RESULTS: Sixty-two patients underwent surgery for high-grade DCIS, and 35 of these patients underwent SLNB. Postsurgical excision histology revealed invasive disease in 20 patients, 19 of whom had undergone SLNB. Before the adoption of SLNB in selected DCIS patients, all 20 with occult invasive disease would have required second surgery axillary staging (P < .01, chi-square test). CONCLUSIONS: SLNB should not be performed routinely for all patients with an initial diagnosis of DCIS. However, selective lymphadenectomy may be a useful clinical adjuvant in selected high-risk DCIS patients.
Authors:
Cathal J Moran; Malcolm R Kell; Fidelma L Flanagan; Maria Kennedy; Thomas F Gorey; Michael J Kerin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of surgery     Volume:  194     ISSN:  1879-1883     ISO Abbreviation:  Am. J. Surg.     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-09     Completed Date:  2007-07-31     Revised Date:  2009-05-20    
Medline Journal Info:
Nlm Unique ID:  0370473     Medline TA:  Am J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  172-5     Citation Subset:  AIM; IM    
Affiliation:
Department of Surgery, National Breast Screening Program, Eccles Unit, University College Dublin, 36 Eccles St, Dublin 7, Ireland.
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MeSH Terms
Descriptor/Qualifier:
Aged
Breast Neoplasms / pathology*,  surgery*
Carcinoma, Intraductal, Noninfiltrating / pathology*,  surgery*
Female
Follow-Up Studies
Humans
Mastectomy
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Predictive Value of Tests
Prospective Studies
Risk Factors
Sentinel Lymph Node Biopsy*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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