| Role of senescence and mitotic catastrophe in cancer therapy. | |
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MedLine Citation:
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PMID: 20205872 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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Senescence and mitotic catastrophe (MC) are two distinct crucial non-apoptotic mechanisms, often triggered in cancer cells and tissues in response to anti-cancer drugs. Chemotherapeuticals and myriad other factors induce cell eradication via these routes. While senescence drives the cells to a state of quiescence, MC drives the cells towards death during the course of mitosis. The senescent phenotype distinguishes tumor cells that survived drug exposure but lost the ability to form colonies from those that recover and proliferate after treatment. Although senescent cells do not proliferate, they are metabolically active and may secrete proteins with potential tumor-promoting activities. The other anti-proliferative response of tumor cells is MC that is a form of cell death that results from abnormal mitosis and leads to the formation of interphase cells with multiple micronuclei. Different classes of cytotoxic agents induce MC, but the pathways of abnormal mitosis differ depending on the nature of the inducer and the status of cell-cycle checkpoints. In this review, we compare the two pathways and mention that they are activated to curb the growth of tumors. Altogether, we have highlighted the possibilities of the use of senescence targeting drugs, mitotic kinases and anti-mitotic agents in fabricating novel strategies in cancer control. |
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Authors:
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Richa Singh; Jasmine George; Yogeshwer Shukla |
Publication Detail:
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Type: Journal Article Date: 2010-01-21 |
Journal Detail:
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Title: Cell division Volume: 5 ISSN: 1747-1028 ISO Abbreviation: Cell Div Publication Date: 2010 |
Date Detail:
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Created Date: 2010-03-08 Completed Date: 2011-07-14 Revised Date: 2011-09-02 |
Medline Journal Info:
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Nlm Unique ID: 101251560 Medline TA: Cell Div Country: England |
Other Details:
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Languages: eng Pagination: 4 Citation Subset: - |
Affiliation:
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Proteomics Laboratory, Indian Institute of Toxicology Research, (Council of Scientific & Industrial Research), PO Box 80, MG Marg, Lucknow-226001, India. yogeshwer_shukla@hotmail.com. |
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