| Role of selective autophagy in cellular remodeling: "self-eating" into shape. | |
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MedLine Citation:
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PMID: 20890115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The Atg1 Ser/Thr kinase, although now a well-established regulator of autophagy, was first identified genetically in C. elegans as a requirement for axonal elongation. However, possible connections between Atg1 functions in cellular morphogenesis and in autophagy were previously unaddressed. In the recent paper highlighted in this punctum, we reconciled these dual roles for Atg1, demonstrating a requirement for p62-mediated selective autophagy in the dynamic regulation of cell shape, in both fly and mammalian macrophages, with effects on immune cell functions. This work further strengthens the emerging importance of autophagy as a post-translational regulatory mechanism in diverse cell signaling contexts, including the cortical remodeling and function of immune cells. |
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Authors:
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Pavan Kadandale; Amy A Kiger |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-11-16 |
Journal Detail:
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Title: Autophagy Volume: 6 ISSN: 1554-8635 ISO Abbreviation: Autophagy Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-16 Completed Date: 2011-03-02 Revised Date: 2011-06-30 |
Medline Journal Info:
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Nlm Unique ID: 101265188 Medline TA: Autophagy Country: United States |
Other Details:
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Languages: eng Pagination: 1194-5 Citation Subset: IM |
Affiliation:
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Section of Cell & Developmental Biology, University of California, San Diego, La Jolla, CA, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Actins
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metabolism Animals Autophagy* Caenorhabditis elegans / cytology Cell Shape* Cells / cytology*, metabolism* Drosophila melanogaster / cytology Lysosomes / metabolism Phagosomes / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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R01 GM078176-05/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Actins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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