Document Detail

Role of the selective aldosterone receptor blockers in arterial hypertension.
MedLine Citation:
PMID:  15136969     Owner:  NLM     Status:  MEDLINE    
Aldosterone can cause cardiovascular injury in animals and men. The aldosterone blocker, spironolactone, has been shown to reduce mortality in patients with congestive heart failure. The use of this drug in arterial hypertension has been limited by the high frequency of adverse effects. Recently published data with a new aldosterone blocker, eplerenone, have confirmed the benefits of aldosterone blockade in patients post-myocardial infarction, as well as in the regression of left ventricular hypertrophy in hypertensive patients and of microalbuminuria in Type 2 diabetic patients. The fact that eplerenone is much better tolerated open the possibility of this therapy in cardiovascular, as well as in renal disease.
Cristina Sierra; Luis M Ruilope
Related Documents :
18760759 - Treatment of hypertension in heart failure with preserved ejection fraction: role of th...
12508909 - Pituitary function in chronic heart failure in the elderly.
10487799 - Increasing the impact of cardiological treatments. how best to reduce deaths.
1736619 - Effect of captopril on cardiac parasympathetic activity in chronic cardiac failure seco...
16036019 - Pharmacologic effects on cardiac remodeling.
9891599 - Medical therapy of chronic heart failure. role of ace inhibitors and beta-blockers.
1078299 - Serum iron, glutamic oxalacetic transaminase and creatine phosphokinase in acute myocar...
15245339 - Temporal analysis of the depolarization wave of healed myocardial infarction in body su...
15678469 - Comparison of the left ventricular electromechanical map before percutaneous coronary s...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of the renin-angiotensin-aldosterone system : JRAAS     Volume:  5     ISSN:  1470-3203     ISO Abbreviation:  J Renin Angiotensin Aldosterone Syst     Publication Date:  2004 Mar 
Date Detail:
Created Date:  2004-05-11     Completed Date:  2004-10-19     Revised Date:  2013-11-25    
Medline Journal Info:
Nlm Unique ID:  100971636     Medline TA:  J Renin Angiotensin Aldosterone Syst     Country:  England    
Other Details:
Languages:  eng     Pagination:  23-5     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Hypertension / drug therapy*
Mineralocorticoid Receptor Antagonists*
Myocardial Infarction / complications
Spironolactone / analogs & derivatives*,  therapeutic use*
Ventricular Dysfunction, Left / drug therapy,  etiology
Reg. No./Substance:
0/Mineralocorticoid Receptor Antagonists; 27O7W4T232/Spironolactone; 6995V82D0B/eplerenone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Blood pressure in haemodialysis patients: the importance of the relationship between the renin-angio...
Next Document:  Dietary sodium restriction specifically potentiates left ventricular ACE inhibition by zofenopril, a...