Document Detail


Role of salivary mucin in the protection of rat esophageal mucosa from acid and pepsin-induced injury.
MedLine Citation:
PMID:  10516145     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mucosal defensive mechanisms of the esophagus against acid and pepsin remain to be elucidated. In the present study, we investigated the contribution of the salivary mucin in maintaining the integrity of the esophageal mucosa. When an everted esophageal sac, isolated from normal rat, was treated with N-acetyl-L-cysteine, a mucolytic agent, the amount of glycoprotein in the gel layer adherent to the epithelium was completely depleted and the susceptibility of the mucosa against acidified pepsin-induced digestion increased. In sialoadenectomized rats, 7 days after extirpation, the amount of glycoprotein adherent to the esophageal epithelium was definitely reduced, and the esophageal mucosa was significantly vulnerable to acidified pepsin-induced digestion compared with the sham-operated rats. Induction of regurgitation of the gastric juices into the esophagus resulted in the development of severe hemorrhagic esophageal lesions only in the sialoadenectomized rats but not in the sham-operated rats. In conclusion, the glycoprotein in the adherent gel layer in rat esophagus, which mainly derives from salivary glands, plays an important role in the preepithelial defense to maintain the integrity of the esophageal mucosa against acid and pepsin.
Authors:
M Kinoshita; E Kume; S Igarashi; N Saito; H Narita
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  277     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Oct 
Date Detail:
Created Date:  1999-11-22     Completed Date:  1999-11-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G796-800     Citation Subset:  IM    
Affiliation:
Tanabe Seiyaku Company, Ltd., Discovery Research Laboratory, Toda, Saitama 335-8505, Japan. mine-k@tanabe.co.jp
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MeSH Terms
Descriptor/Qualifier:
Acetylcysteine / pharmacology
Acids
Animals
Epidermal Growth Factor / pharmacology
Esophageal Diseases / chemically induced*,  prevention & control*
Esophagus / physiology*
Male
Mucins / physiology*
Mucous Membrane / physiology
Pepsin A / antagonists & inhibitors
Rats
Rats, Sprague-Dawley
Salivary Glands / metabolism*,  physiology
Chemical
Reg. No./Substance:
0/Acids; 0/Mucins; 616-91-1/Acetylcysteine; 62229-50-9/Epidermal Growth Factor; EC 3.4.23.1/Pepsin A

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