Document Detail


Role of rs1533428 and rs12994401 in patients with Primary Open Angle Glaucoma in an European population.
MedLine Citation:
PMID:  23136999     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Purpose: Genetic factors have been shown to play a remarkable role in the pathophysiology of glaucoma. Recently, two polymorphisms (rs1533428 and rs12994401) on chromosome 2p were found to be strongly associated with POAG in an Afro-Caribbean population in Barbados, West Indies. As data with regard to the role of these polymorphisms in a Caucasian population are lacking, the present study was set to investigate a hypothetical association between these polymorphisms and POAG in a Caucasian population. Methods: In total 723 participants were included in this study comprising 366 patients with POAG and 357 control subjects from the southern part of Austria. Genotyping of rs1533428 and rs12994401 was performed using polymerase chain reaction. Results: Allelic frequencies and genotype distributions of rs1533428 and rs12994401 did not show statistical significance between patients with POAG and control subjects (p < 0.05). Presence of the rs1533428 T-allele was associated with an odds ratio of 0.95 (95% CI: 0.76-1.19; p = 0.69) for POAG, while the rs12994401 T-allele was associated with an odds ratio of 0.94 (95% CI: 0.73-1.21; p = 0.65) for POAG. Conclusion: Our data suggest that rs1533428 and rs12994401 themselves are unlikely major risk factors for POAG in a Central European population.
Authors:
Alexander Bachernegg; Yosuf El-Shabrawi; Martin Weger; Georg Mossböck
Related Documents :
16247549 - Pax9 and tgfb3 are linked to susceptibility to nonsyndromic cleft lip with or without c...
23233309 - An activity-enhancing variant of irak1 and an mecp2-irak1 haplotype associating with in...
23289029 - Il-18 gene promoter polymorphisms are only moderately associated with periodontal disea...
17345049 - Study of cerebral cavernous malformation in spain and portugal: high prevalence of a 14...
23725549 - Expanding the environment: gene × school-level ses interaction on reading comprehension.
24705699 - Genetic correlations between growth and reproductive traits in zandi sheep.
4538909 - Secondary association in populations due to heterogeneity.
17618459 - Heterozygous abca3 mutation associated with non-fatal evolution of respiratory distress.
10077729 - Linkage disequilibrium and haplotype analysis in german friedreich ataxia families.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-9
Journal Detail:
Title:  Ophthalmic genetics     Volume:  -     ISSN:  1744-5094     ISO Abbreviation:  Ophthalmic Genet.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9436057     Medline TA:  Ophthalmic Genet     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University Eye Clinic, Paracelsus Medical University, Müllner Hauptstraße 48 , A-5020 Salzburg , Austria.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Discriminative EPR detection of NO and HNO by encapsulated nitronyl nitroxides.
Next Document:  Novel susceptibility genes associated with diabetic cataract in a Taiwanese population.