Document Detail

Role of routine monitoring of liver and renal function during treatment of ectopic pregnancies with single-dose methotrexate protocol.
MedLine Citation:
PMID:  22521698     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To assess whether or not baseline serum transaminases and creatinine measurements, before administration of methotrexate, identified significant liver or kidney disease, which have the potential to alter the management plan for the treatment of ectopic pregnancies. DESIGN: This is a retrospective study of patients treated for ectopic pregnancy. SETTING: Women's emergency room and reproductive endocrinology office at a teaching hospital over a 3-year period. PATIENT(S): Women presenting for treatment of ectopic pregnancy. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Assessment of baseline serum transaminases and creatinine measurements before administration of methotrexate to identify significant liver or kidney disease. RESULT(S): A total of 383 patients were managed for ectopic pregnancy from January 2006 to December 2008. Of these, 320 patients received methotrexate as part of their treatment. No patient was denied treatment with methotrexate secondary to concerns regarding liver or renal function. No complication related to methotrexate administration was documented. A subgroup of 81 patients had pre- and postadministration labs, and no significant difference was noted upon comparing the values. CONCLUSION(S): Routine measurement of serum aspartate aminotransferase and creatinine levels may not be necessary before instituting a single-dose methotrexate treatment regimen for the management of ectopic pregnancy.
Lindsay E Clark; Bala Bhagavath; Carol A Wheeler; Gary N Frishman; Sandra A Carson
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-20
Journal Detail:
Title:  Fertility and sterility     Volume:  -     ISSN:  1556-5653     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
Women and Infants Hospital, Department of Obstetrics and Gynecology and the Warren Alpert Medical School at Brown University, Providence, Rhode Island.
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