Document Detail

Role of reversible phosphorylation in mediating changes in the activity of hepatic 3-hydroxy-3-methylglutaryl-CoA reductase during pregnancy and lactation in the rat.
MedLine Citation:
PMID:  3435498     Owner:  NLM     Status:  MEDLINE    
1. The expressed and total (completely dephosphorylated) activities of 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase were measured in microsomal fractions isolated from cold-clamped liver samples from female rats in various stages of the reproductive cycle. 2. There was little change in total HMG-CoA reductase activity during pregnancy and early lactation, but after 2 days post partum there was a marked increase in total activity. 3. The expressed/total activity ratio of HMG-CoA reductase showed a profound decrease during the last 2 days of pregnancy. The fraction of the enzyme in the active form increased progressively during the first 2 days of lactation. 4. The combined effect of these changes was that the expressed activity of HMG-CoA reductase changed in parallel with the known changes in the hepatic rate of cholesterogenesis during pregnancy and lactation in vivo.
R A Easom; V A Zammit
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  248     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-03-15     Completed Date:  1988-03-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  993-6     Citation Subset:  IM    
Hannah Research Institute, Ayr, Scotland, U.K.
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MeSH Terms
Hydroxymethylglutaryl CoA Reductases / metabolism*
Hydroxymethylglutaryl-CoA-Reductases, NADP-dependent
Lactation / metabolism*
Liver / enzymology*
Microsomes, Liver / enzymology
Pregnancy, Animal / metabolism*
Rats, Inbred Strains
Reg. No./Substance:
EC 1.1.1.-/Hydroxymethylglutaryl CoA Reductases; EC, NADP-dependent

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