| Role of residual flow on the neuroprotective efficacy of human albumin in the rat with transient cerebral ischemia. | |
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MedLine Citation:
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PMID: 19508826 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: It is well known that residual cortical cerebral blood flow plays a pivotal role in the pathophysiology of cerebral ischemia and can influence the outcome of recanalization therapy. This study examined the impact of residual cortical cerebral blood flow on the neuroprotective efficacy of human albumin in a rat transient cerebral ischemia model. METHODS: Sprague-Dawley rats were subjected to 2 hour middle cerebral artery occlusion. According to different magnitudes of residual cortical cerebral blood flow during cerebral ischemia, rats were divided into three groups: Group I, cerebral blood flow <25% of the baseline; Group II, cerebral blood flow between 25 and 50% of the baseline; Group III, cerebral blood flow >50% of the baseline. The infarct volume and brain swelling were observed after 48 hours of reperfusion. Neurological scores and motor function were also evaluated. RESULTS: After 2 days of reperfusion, human albumin therapy significantly (p<0.01) reduced total infarct volume and improved the neurological and motor function compared with the stroke group only in Group II. In Group I and in Group III, whether human albumin was administered or not, rats in Group I always showed a poor outcome and rats in Group III always showed an excellent outcome. CONCLUSION: Our study suggests that human albumin has neuroprotection in acute stroke treatment only within a magnitude range of residual cortical cerebral blood flow during ischemia. |
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Authors:
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Jian Chen; Xunming Ji; Yuchuan Ding; Yumin Luo; Huakun Cheng; Feng Ling |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurological research Volume: 31 ISSN: 0161-6412 ISO Abbreviation: Neurol. Res. Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-06-10 Completed Date: 2009-07-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905298 Medline TA: Neurol Res Country: England |
Other Details:
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Languages: eng Pagination: 396-401 Citation Subset: IM |
Affiliation:
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Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing 100053, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Albumins
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therapeutic use* Analysis of Variance Animals Behavior, Animal Blood Flow Velocity / drug effects Cerebral Infarction / complications, prevention & control Cerebrovascular Circulation / drug effects* Disease Models, Animal Humans Ischemic Attack, Transient / classification, drug therapy* Laser-Doppler Flowmetry / methods Male Motor Activity / drug effects Neurologic Examination / methods Neuroprotective Agents / therapeutic use* Psychomotor Performance / drug effects Rats Rats, Sprague-Dawley Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Albumins; 0/Neuroprotective Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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