Document Detail

Role of the renin-angiotensin system in hypertension produced by unilateral renal artery constriction in the rat.
MedLine Citation:
PMID:  971555     Owner:  NLM     Status:  MEDLINE    
1. Conscious rats which had undergone unilateral renal artery constriction were infused for 1 h with a specific antagonist of angiotensin II, 1-Sar-8-Ala-angiotensin II (P-113). 2. There was a highly significant correlation between the change in blood pressure induced by P-113 and the pre-infusion plasma renin concentration (PRC), regardless of initial blood pressure or the duration of stenosis. However, the blood pressure fall was not significantly greater in nineteen hypertensive rats than in eleven which remained normotensive. P-113 did not abolish the hypertension. 3. The extent to which angiotensin II supports blood pressure in rats with renal artery constriction is directly related to the PRC.
H F Oates
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical and experimental pharmacology & physiology     Volume:  3     ISSN:  0305-1870     ISO Abbreviation:  Clin. Exp. Pharmacol. Physiol.     Publication Date:    1976 Jan-Feb
Date Detail:
Created Date:  1976-12-03     Completed Date:  1976-12-03     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0425076     Medline TA:  Clin Exp Pharmacol Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / physiology*
Blood Pressure / drug effects*
Renal Artery Obstruction / physiopathology*
Renin / blood,  physiology*
Saralasin / pharmacology
Reg. No./Substance:
11128-99-7/Angiotensin II; 34273-10-4/Saralasin; EC

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