Document Detail

Role of the renin-angiotensin system in arterial hypertension secondary to acute unilateral urinary obstruction.
MedLine Citation:
PMID:  7899578     Owner:  NLM     Status:  MEDLINE    
Acute unilateral ureteral obstruction (AUUO) has been associated to a blood pressure increase, presumably secondary to activation of the renin-angiotensin system (RAS), since the obstructed kidney increases renin secretion (Ref. 8). In an attempt to delineate the role of the RAS in this hypertensive model, we acutely obstructed the ureter in two groups of dogs that previous to the obstruction received either placebo (G I, n = 8) or 50 mg of captopril, an angiotensin-converting enzyme inhibitor (G II, n = 9). Animals that received placebo showed a consistent increase in mean arterial pressure (MAP), 128 +/- 4 vs. 144 +/- 4 mm Hg (p < 0.001); those that received captopril did not show such a tendency: 135 +/- 7 vs. 135 +/- 7 mm Hg. In further studies, three groups of animals were included: group III (G III, n = 4), identical to G I except that plasma renin activity (PRA) and aldosterone (ALDO) were measured; Group IV (G IV, n = 5), identical to G II except that they received 50 mg of indomethacin, 60 min before captopril; and group V (G V, n = 6), which was sham operated and measured for PRA and ALDO.(ABSTRACT TRUNCATED AT 250 WORDS)
G Hernández-Llamas; G Palafox-Cervantes; A L Borboa-Osuna; J Urrecha-Manzano; C Cruz; J Pedraza-Chaverrí; C Cuetos-Martínez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Renal failure     Volume:  16     ISSN:  0886-022X     ISO Abbreviation:  Ren Fail     Publication Date:  1994 Nov 
Date Detail:
Created Date:  1995-04-25     Completed Date:  1995-04-25     Revised Date:  2008-05-21    
Medline Journal Info:
Nlm Unique ID:  8701128     Medline TA:  Ren Fail     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  673-9     Citation Subset:  IM    
Unidad de Medicina y Cirugía Experimental, Universidad Autónoma de Sinaola, Mexico.
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MeSH Terms
Aldosterone / metabolism
Blood Pressure / drug effects
Captopril / pharmacology*
Disease Models, Animal
Hypertension / etiology*,  metabolism,  prevention & control
Renin / metabolism
Renin-Angiotensin System / drug effects,  physiology*
Ureteral Obstruction / complications*,  physiopathology
Reg. No./Substance:
52-39-1/Aldosterone; 62571-86-2/Captopril; EC

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