Document Detail

Role of the renin-angiotensin system in hypertension in the elderly.
MedLine Citation:
PMID:  7889195     Owner:  NLM     Status:  MEDLINE    
Although the activity of the renin-angiotensin system is known to decrease with age, the antihypertensive efficacy of angiotensin-converting enzyme (ACE) inhibitors has been demonstrated in the elderly. To examine the role of the renin-angiotensin system in hypertension in the elderly, we evaluated the antihypertensive response to enalapril and to TCV-116, an angiotensin II type-1 receptor antagonist, in elderly patients with essential hypertension. A single oral dose of enalapril (10 mg) increased plasma renin activity (PRA) and reduced the angiotensin II concentration, whereas a single oral dose of TCV-116 (4 mg) increased both PRA and the angiotensin II concentration. Blood pressure was significantly reduced by these drugs from 4 h after administration. Basal levels of PRA and angiotensin II declined with age. However, the changes in blood pressure produced by either TCV-116 or enalapril did not correlate with age. These results suggest that the activity of the renin-angiotensin system in plasma declines with age, and that the extrarenal renin-angiotensin system may play a role in hypertension in the elderly.
M Nagano; J Higaki; H Mikami; T Ogihara
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Blood pressure. Supplement     Volume:  5     ISSN:  0803-8023     ISO Abbreviation:  Blood Press Suppl     Publication Date:  1994  
Date Detail:
Created Date:  1995-04-20     Completed Date:  1995-04-20     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9300787     Medline TA:  Blood Press Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  130-3     Citation Subset:  IM    
Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan.
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MeSH Terms
Aging / physiology*
Angiotensin II / blood
Angiotensin Receptor Antagonists*
Antihypertensive Agents / therapeutic use*
Benzimidazoles / adverse effects,  therapeutic use*
Biphenyl Compounds / adverse effects,  therapeutic use*
Blood Pressure / drug effects
Enalapril / adverse effects,  therapeutic use*
Hypertension / blood,  drug therapy*,  physiopathology*
Middle Aged
Prodrugs / therapeutic use*
Renin / blood
Renin-Angiotensin System / drug effects*,  physiology*
Reg. No./Substance:
0/Angiotensin Receptor Antagonists; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Biphenyl Compounds; 0/Prodrugs; 0/Tetrazoles; 11128-99-7/Angiotensin II; 75847-73-3/Enalapril; EC; R85M2X0D68/candesartan cilexetil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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