Document Detail


Role of the renin-angiotensin system in hypertension in the elderly.
MedLine Citation:
PMID:  7889195     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although the activity of the renin-angiotensin system is known to decrease with age, the antihypertensive efficacy of angiotensin-converting enzyme (ACE) inhibitors has been demonstrated in the elderly. To examine the role of the renin-angiotensin system in hypertension in the elderly, we evaluated the antihypertensive response to enalapril and to TCV-116, an angiotensin II type-1 receptor antagonist, in elderly patients with essential hypertension. A single oral dose of enalapril (10 mg) increased plasma renin activity (PRA) and reduced the angiotensin II concentration, whereas a single oral dose of TCV-116 (4 mg) increased both PRA and the angiotensin II concentration. Blood pressure was significantly reduced by these drugs from 4 h after administration. Basal levels of PRA and angiotensin II declined with age. However, the changes in blood pressure produced by either TCV-116 or enalapril did not correlate with age. These results suggest that the activity of the renin-angiotensin system in plasma declines with age, and that the extrarenal renin-angiotensin system may play a role in hypertension in the elderly.
Authors:
M Nagano; J Higaki; H Mikami; T Ogihara
Related Documents :
7712695 - Cardiovascular and hormonal responses to anaphylactic shock in the pig.
8282375 - Role of nitric oxide in the renin and heart rate responses to beta-adrenergic stimulation.
9848775 - Pressure-natriuresis and -diuresis in transgenic rats harboring both human renin and hu...
2244565 - Effects of renin inhibition in systemic hypertension.
2096205 - Clinical assessment of blood pressure.
931935 - Delineation of flow-limiting segment and predicted airway resistance by movable catheter.
Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Blood pressure. Supplement     Volume:  5     ISSN:  0803-8023     ISO Abbreviation:  Blood Press Suppl     Publication Date:  1994  
Date Detail:
Created Date:  1995-04-20     Completed Date:  1995-04-20     Revised Date:  2013-05-28    
Medline Journal Info:
Nlm Unique ID:  9300787     Medline TA:  Blood Press Suppl     Country:  NORWAY    
Other Details:
Languages:  eng     Pagination:  130-3     Citation Subset:  IM    
Affiliation:
Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Aging / physiology*
Angiotensin II / blood
Angiotensin Receptor Antagonists*
Antihypertensive Agents / therapeutic use*
Benzimidazoles / adverse effects,  therapeutic use*
Biphenyl Compounds / adverse effects,  therapeutic use*
Blood Pressure / drug effects
Enalapril / adverse effects,  therapeutic use*
Humans
Hypertension / blood,  drug therapy*,  physiopathology*
Middle Aged
Prodrugs / therapeutic use*
Renin / blood
Renin-Angiotensin System / drug effects*,  physiology*
Tetrazoles*
Chemical
Reg. No./Substance:
0/Angiotensin Receptor Antagonists; 0/Antihypertensive Agents; 0/Benzimidazoles; 0/Biphenyl Compounds; 0/Prodrugs; 0/Tetrazoles; 11128-99-7/Angiotensin II; 75847-73-3/Enalapril; EC 3.4.23.15/Renin; R85M2X0D68/candesartan cilexetil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effect of an angiotensin receptor antagonist, TCV-116, on sympathetic nerve activity in patients wit...
Next Document:  Regional haemodynamic effects of the novel AT1 receptor antagonist, CV-11974, in conscious rats.