| Role of the renal kallikrein-kinin system in the development of salt-sensitive hypertension. | |
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MedLine Citation:
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PMID: 11258674 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of the renal kallikrein-kinin system in the development of salt-sensitive hypertension was studied using mutant kininogen-deficient Brown-Norway Katholiek (BN-Ka) rats, which generate no kinin in their urine, and other hypertensive rat models. It was found that ingestion of a low sodium diet or infusion of NaCl in doses slightly above 0.15 M caused hypertension and sodium accumulation in erythrocytes and the cerebrospinal fluid of kininogen-deficient BN-Ka rats. Development of hypertension in the deoxycorticosterone-acetate-salt model was completely prevented by administration of a newly discovered inhibitor, ebelactone B, of carboxypeptidase Y-like exopeptidase (an urinary kininase). The urinary kallikrein excretion of spontaneously hypertensive rats was lower than that of Wistar Kyoto rats at 4 weeks of age and did not increase by administration of furosemide, a diuretic agent, although approximately 50% of the diuretic action of this agent was dependent upon the renal kallikrein-kinin system in normal rats. In conclusion, the renal kallikrein-kinin system works as a safety valve for excess sodium intake. |
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Authors:
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M Katori; M Majima; I Hayashi; T Fujita; M Yamanaka |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Biological chemistry Volume: 382 ISSN: 1431-6730 ISO Abbreviation: Biol. Chem. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-03-21 Completed Date: 2001-09-13 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9700112 Medline TA: Biol Chem Country: Germany |
Other Details:
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Languages: eng Pagination: 61-4 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Kitasato University School of Medicine, Sagamihara, Kanagawa, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antihypertensive Agents / pharmacology Hypertension / drug therapy, physiopathology* Kallikrein-Kinin System / drug effects, physiology* Kidney / physiopathology* Rats Rats, Inbred BN Rats, Inbred SHR |
| Chemical | |
Reg. No./Substance:
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0/Antihypertensive Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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