| Role of renal and extrarenal renin-angiotensin system in the mechanism of arterial hypertension and its sequelae. | |
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MedLine Citation:
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PMID: 8116011 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The role of the renin-angiotensin system in cardiovascular function and disease has long been recognized. The renin-angiotensin system was originally thought to be only active in the plasma as a circulating endocrine system, controlling blood pressure and electrolyte homeostasis. The recent introduction of new biotechnologies to cardiovascular research has demonstrated that the renin-angiotensin system can operate as both an endocrine (circulating) and an autocrine/paracrine (tissue) system. The endocrine component is involved with acute circulating homeostasis, whereas it is believed that the tissue renin-angiotensin system participates in the tonic regulation of cardiovascular function and structure. Multiple lines of evidence support the presence of complete renin-angiotensin systems in the central nervous system, vasculature, adrenal, heart, kidney, and reproductive organs. Although more research is necessary to delineate the role of tissue renin-angiotensin systems in local tissue function, the significant contribution of the renin-angiotensin system in the pathophysiology of cardiovascular disease is increasingly apparent (Table 1). |
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Authors:
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J Rosenthal |
Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Steroids Volume: 58 ISSN: 0039-128X ISO Abbreviation: Steroids Publication Date: 1993 Dec |
Date Detail:
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Created Date: 1994-03-25 Completed Date: 1994-03-25 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0404536 Medline TA: Steroids Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 566-72 Citation Subset: IM |
Affiliation:
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Section Pharmacotherapy, Ulm University Medical Center, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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physiopathology Angiotensin-Converting Enzyme Inhibitors / pharmacology Animals Blood Vessels / physiopathology Central Nervous System / physiopathology Heart / physiopathology Humans Hypertension / physiopathology* Kidney / physiopathology* Renin-Angiotensin System* Urogenital System / physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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