Document Detail

Role of renal and extrarenal renin-angiotensin system in the mechanism of arterial hypertension and its sequelae.
MedLine Citation:
PMID:  8116011     Owner:  NLM     Status:  MEDLINE    
The role of the renin-angiotensin system in cardiovascular function and disease has long been recognized. The renin-angiotensin system was originally thought to be only active in the plasma as a circulating endocrine system, controlling blood pressure and electrolyte homeostasis. The recent introduction of new biotechnologies to cardiovascular research has demonstrated that the renin-angiotensin system can operate as both an endocrine (circulating) and an autocrine/paracrine (tissue) system. The endocrine component is involved with acute circulating homeostasis, whereas it is believed that the tissue renin-angiotensin system participates in the tonic regulation of cardiovascular function and structure. Multiple lines of evidence support the presence of complete renin-angiotensin systems in the central nervous system, vasculature, adrenal, heart, kidney, and reproductive organs. Although more research is necessary to delineate the role of tissue renin-angiotensin systems in local tissue function, the significant contribution of the renin-angiotensin system in the pathophysiology of cardiovascular disease is increasingly apparent (Table 1).
J Rosenthal
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Steroids     Volume:  58     ISSN:  0039-128X     ISO Abbreviation:  Steroids     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-03-25     Completed Date:  1994-03-25     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0404536     Medline TA:  Steroids     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  566-72     Citation Subset:  IM    
Section Pharmacotherapy, Ulm University Medical Center, Germany.
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MeSH Terms
Adrenal Glands / physiopathology
Angiotensin-Converting Enzyme Inhibitors / pharmacology
Blood Vessels / physiopathology
Central Nervous System / physiopathology
Heart / physiopathology
Hypertension / physiopathology*
Kidney / physiopathology*
Renin-Angiotensin System*
Urogenital System / physiopathology
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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