| Role of regulatory elements and the MAPK/ERK or p38 MAPK pathways for activation of human cytomegalovirus gene expression. | |
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MedLine Citation:
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PMID: 11967304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A series of recombinant viruses with either site-specific mutations or various deletions of the early UL4 promoter of human cytomegalovirus were used to determine the roles of regulatory elements and the effects of the mitogen-activated protein kinase (MAPK) pathways. Viral gene expression was regulated by upstream cis-acting sites and by basic promoter elements that respond to the MAPK signal transduction pathways. Inhibitors of either the mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) pathway or the p38 MAPK pathway affected expression equally with either wild-type or mutant early UL4 promoters in the viral genome, indicating that the effects of the inhibitors are not exclusive for a single transcription factor. The minimal responsive element is the TATA box-containing early viral promoter. |
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Authors:
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Jiping Chen; Mark F Stinski |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of virology Volume: 76 ISSN: 0022-538X ISO Abbreviation: J. Virol. Publication Date: 2002 May |
Date Detail:
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Created Date: 2002-04-22 Completed Date: 2002-06-07 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 0113724 Medline TA: J Virol Country: United States |
Other Details:
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Languages: eng Pagination: 4873-85 Citation Subset: IM |
Affiliation:
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Department of Microbiology, College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blotting, Northern Cell Line Cytomegalovirus / genetics* DNA-Binding Proteins* Gene Expression Regulation, Viral* Humans Mitogen-Activated Protein Kinase Kinases / metabolism* Mitogen-Activated Protein Kinases / metabolism* Mutation Promoter Regions, Genetic Proto-Oncogene Proteins / metabolism Recombination, Genetic Signal Transduction Transcription Factors / metabolism Viral Envelope Proteins / metabolism* ets-Domain Protein Elk-1 p38 Mitogen-Activated Protein Kinases |
| Grant Support | |
ID/Acronym/Agency:
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AI-13562/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA-Binding Proteins; 0/Proto-Oncogene Proteins; 0/Transcription Factors; 0/UL4 protein, Human cytomegalovirus; 0/Viral Envelope Proteins; 0/ets-Domain Protein Elk-1; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 2.7.11.24/p38 Mitogen-Activated Protein Kinases; EC 2.7.12.2/Mitogen-Activated Protein Kinase Kinases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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