Document Detail


Role of redox in fetal development and neonatal diseases.
MedLine Citation:
PMID:  14713346     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In the cell, reducing and oxidizing molecules modulate the redox state. In embryonic and fetal growth, increased oxidative stress may be detrimental, but an oxidized state can also be beneficial. This is because redox may also affect key transcription factors that can alter gene expression during development. In addition, redox may impact on placentation and amniotic membrane integrity during pregnancy. Lastly, diseases of prematurity, such as necrotizing enterocolitis, retinopathy of prematurity, and chronic lung disease, may be modulated by redox in the premature. Because antioxidant therapies have not necessarily modified the outcome of these diseases, some debate exists as to this. Nonetheless, sufficient evidence suggests a role for redox throughout embryonic, fetal, and postnatal development. This evidence will be explored here.
Authors:
Phyllis A Dennery
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  6     ISSN:  1523-0864     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-09     Completed Date:  2004-09-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  147-53     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Pennsylvania, Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA. dennery@email.chop.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Embryonic and Fetal Development / genetics,  physiology*
Female
Gene Expression Regulation, Developmental
Humans
Infant, Newborn
Infant, Newborn, Diseases / embryology,  metabolism*,  pathology
Oxidation-Reduction*
Pregnancy

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