Document Detail

Role of reactive oxygen metabolites in early cardiopulmonary changes of acute hemorrhagic pancreatitis.
MedLine Citation:
PMID:  2791809     Owner:  NLM     Status:  MEDLINE    
The role of reactive oxygen metabolites in extrapancreatic organ dysfunction associated with acute hemorrhagic pancreatitis was studied in dogs. Experimental pancreatitis was induced by the intraductal infusion of activated trypsin and taurocholate. Cardiac output, pulmonary and systemic blood pressure, pulmonary wedge pressure, central venous pressure, heart rate, blood gases and serum amylase were measured. Cardiac index, pulmonary and systemic vascular resistance, and the right and left stroke work were calculated. Systemic arterial and venous blood pressure and cardiac index gradually declined over 6 hr, while pulmonary mean blood pressure and pulmonary vascular resistance increased. Pretreatment of pancreatitis with catalase and superoxide dismutase prevented the rise in mean pulmonary blood pressure, moderated the rise in pulmonary vascular resistance, and decreased the rate and extent of the fall in cardiac index. These data suggest that reactive oxygen metabolites may play some role in the extraabdominal organ manifestations of acute pancreatitis.
R Chardavoyne; A Asher; S Bank; T A Stein; L Wise
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  34     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  1989 Oct 
Date Detail:
Created Date:  1989-11-08     Completed Date:  1989-11-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1581-4     Citation Subset:  AIM; IM    
Department of Surgery, Long Island Jewish Medical Center, New Hyde Park, New York.
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MeSH Terms
Acute Disease
Catalase / therapeutic use
Free Radicals
Heart Diseases / etiology*,  physiopathology
Lung Diseases / etiology*,  physiopathology
Oxygen / physiology*
Pancreatitis / complications,  physiopathology*
Superoxide Dismutase / therapeutic use
Vascular Resistance
Reg. No./Substance:
0/Free Radicals; 7782-44-7/Oxygen; EC; EC Dismutase

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