| Role of quantitative chest perfusion computed tomography in detecting diabetic pulmonary microangiopathy. | |
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MedLine Citation:
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PMID: 21129800 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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AIMS: aim of the study was to determine the role of perfusion chest computed tomography (pCT) in evaluation of pulmonary diabetic angiopathy. METHODS: 18 never-smoking patients (10 diabetic patients and 8 healthy controls) underwent chest high resolution CT (HRCT) and then pCT scanning. In both groups, blood tests, biochemical analysis, fibrinogen, HbA(1c), spirometry, diffusion capacity for carbon monoxide (DLCO) and body pletysmography were performed.Following parameters of pulmonary perfusion have been analysed: blood volume (BV), blood flow (BF), mean transit time (MTT), time to peak (TTP) and permeability surface (PS). RESULTS: there were no statistically significant differences between groups in terms of age, sex, BMI, forced expiratory volume in one second (FEV(1)), DLCO. Chest HRCT revealed no pathologies. Significantly higher values of chest pCT for BF (p=0.05), BV (p=0.05) and PS (p=0.01) have been found in diabetics in comparison to controls. No differences were found in MTT. CONCLUSIONS: significant increase of perfusion parameters in diabetes seems to confirm pulmonary microangiopathy. The results indicate that further studies on application of pCT in diabetic patients may be beneficial for better understanding of lung microangiopathy, its diagnosing and monitoring. |
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Authors:
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K Kuziemski; J Pieńkowska; W Słomiński; K Specjalski; K Dziadziuszko; E Jassem; M Studniarek; R Kalicka; J M Słomiński |
Publication Detail:
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Type: Journal Article Date: 2010-12-03 |
Journal Detail:
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Title: Diabetes research and clinical practice Volume: 91 ISSN: 1872-8227 ISO Abbreviation: Diabetes Res. Clin. Pract. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8508335 Medline TA: Diabetes Res Clin Pract Country: Ireland |
Other Details:
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Languages: eng Pagination: 80-6 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Ireland Ltd. All rights reserved. |
Affiliation:
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Department of Allergology, Medical University of Gdansk, ul. Dębinki 7, 80-211 Gdansk, Poland. k.kuziemski@gumed.edu.pl |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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