Document Detail


Role of pulmonary phagocytes in host defense against group B streptococci in preterm versus term rabbit lung.
MedLine Citation:
PMID:  1527417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Intrapulmonary clearance of group B streptococci (GBS) occurred in term rabbits 4 and 8 h after infection; GBS growth was evident in preterm rabbits at 8 h. Bronchoalveolar lavage revealed 17-fold higher numbers of pulmonary alveolar macrophages (PAM) in term versus preterm animals immediately after infection, whereas polymorphonuclear leukocyte (PMNL) recruitment was 13-fold greater in preterm than term rabbits at 8 h. Anti-CD18 monoclonal antibody R15.7 did not reduce PMNL influx or GBS killing in term animals. R15.7 failed to inhibit PMNL influx but augmented GBS growth in preterm animals. R15.7 significantly impaired GBS phagocytosis by preterm and term PMNL in vitro but had no effect on ingestion of GBS by preterm and term PAM. Thus, GBS infection initiates PMNL recruitment into lungs of preterm rabbits by CD18-independent mechanisms, but phagocytosis of GBS by PMNL is largely CD18-dependent. The poorer outcome of GBS pneumonia in preterm versus term newborns may result from low levels of PAM, thereby mandating recruitment of PMNL as a second phagocytic defense.
Authors:
M P Sherman; J T Johnson; R Rothlein; B J Hughes; C W Smith; D C Anderson
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  166     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1992 Oct 
Date Detail:
Created Date:  1992-10-22     Completed Date:  1992-10-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  818-26     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, UCLA School of Medicine 90024-1752.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn / immunology
Bronchoalveolar Lavage Fluid / immunology
Fetus / immunology
Lung / immunology*
Macrophages, Alveolar / immunology
Phagocytes / immunology*
Pneumonia / immunology,  microbiology*
Rabbits
Streptococcal Infections / immunology*
Streptococcus agalactiae*
Grant Support
ID/Acronym/Agency:
AI-19301/AI/NIAID NIH HHS; AI-23531/AI/NIAID NIH HHS; HL-40675/HL/NHLBI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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