Document Detail


Role of proteases in patients with acute renal failure and regular hemodialysis therapy.
MedLine Citation:
PMID:  2450393     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potential role of proteases in patients with acute renal failure and regular hemodialysis therapy was investigated. Proteases released from blood cells, damaged kidney cortex and different strains of Pseudomonas aeruginosa in patients with septicemia may contribute to an accelerated protein catabolism. The imbalance of the protease-antiprotease system suggests the valve of active antiproteolytic agents in the treatment of these pathologic states. Our own observation of an in vitro suppression of enhanced proteolysis by the administration of alpha 2-macroglobulin seems to support the usefulness of such a procedure (W.H. Hörl, C. Gautert, I.O. Auer et al., Am. J. Nephrol., 2 (1982) 32-35). As long as alpha 2-macroglobulin is not available, the value of its treatment has to be confirmed by the administration of fresh frozen plasma containing alpha 2-macroglobulin. Also the search for other active antiproteolytic agents is required.
Authors:
W H Hörl; A Heidland
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Resuscitation     Volume:  16     ISSN:  0300-9572     ISO Abbreviation:  Resuscitation     Publication Date:  1988 Jan 
Date Detail:
Created Date:  1988-04-18     Completed Date:  1988-04-18     Revised Date:  2009-08-25    
Medline Journal Info:
Nlm Unique ID:  0332173     Medline TA:  Resuscitation     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  65-74     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Freiburg and Würzburg, F.R.G.
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MeSH Terms
Descriptor/Qualifier:
Humans
Kidney Failure, Acute / enzymology*,  therapy
Peptide Hydrolases / metabolism*
Renal Dialysis
alpha-Macroglobulins / metabolism
Chemical
Reg. No./Substance:
0/alpha-Macroglobulins; EC 3.4.-/Peptide Hydrolases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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