Document Detail


Role of progesterone and progestin therapy in threatened abortion and preterm labour.
MedLine Citation:
PMID:  17981685     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Progesterone (P) has been widely used in an attempt to prevent threatened miscarriage, recurrent miscarriage and pre-term labour. Successful pregnancy depends on maternal tolerance of the fetal "semi-allograft". Along with its endocrine effects, P also acts as an "immunosteroid", by controlling the bias towards a pregnancy protective immune milieu. A protein called progesterone-induced blocking factor (PIBF), by inducing a Th2 dominant cytokine production mediates the immunological effects of progesterone. Progesterone plays a role in uterine homing of NK cells and up-regulates HLA-G gene expression, the ligand for various NK inhibitory receptors. At high concentrations, progesterone is a potent inducer of Th2-type cytokines as well as of LIF and M-CSF production by T cells. The possible mechanisms by which progesterone contributes to the maintenance of early and late pregnancy are discussed.
Authors:
Julia Szekeres-Bartho; Jacek R Wilczynski; Pawel Basta; Jaroslaw Kalinka
Related Documents :
9524155 - Decreased approximate entropy of heart rate variability in the hypoxic ovine fetus
1271355 - Preliminary results on plasma progesterone levels during pregnancy and superfetation in...
21220735 - Association of maternal diabetes mellitus in pregnancy with offspring adiposity into ea...
9011015 - Effect of toxoplasma gondii infection on the development of pregnancy and on endocrine ...
17712645 - Management of primary abdominal pregnancy: twelve years of experience in a medical centre.
22152645 - Perception of teratogenic risk and the rated likelihood of pregnancy termination: assoc...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-01-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  13     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2008  
Date Detail:
Created Date:  2007-11-05     Completed Date:  2007-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1981-90     Citation Subset:  IM    
Affiliation:
Department of Medical Microbiology and Immunology, Medical School, Pecs University, H-7643 Pecs, Hungary. Julia.szekeres@aok.pte.hu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Threatened / metabolism*
Animals
Cytokines / metabolism
Female
Humans
Inflammation
Killer Cells, Natural / metabolism
Monocytes / metabolism
Obstetric Labor, Premature / metabolism*
Oxidative Stress
Pregnancy
Progesterone / metabolism,  physiology*
Progestins / therapeutic use*
Prostaglandins / metabolism
Chemical
Reg. No./Substance:
0/Cytokines; 0/Progestins; 0/Prostaglandins; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The VesiVax system: a method for rapid vaccine development.
Next Document:  Mosaic serine proteases in the mammalian central nervous system.