Document Detail

Role of progesterone and progestin therapy in threatened abortion and preterm labour.
MedLine Citation:
PMID:  17981685     Owner:  NLM     Status:  MEDLINE    
Progesterone (P) has been widely used in an attempt to prevent threatened miscarriage, recurrent miscarriage and pre-term labour. Successful pregnancy depends on maternal tolerance of the fetal "semi-allograft". Along with its endocrine effects, P also acts as an "immunosteroid", by controlling the bias towards a pregnancy protective immune milieu. A protein called progesterone-induced blocking factor (PIBF), by inducing a Th2 dominant cytokine production mediates the immunological effects of progesterone. Progesterone plays a role in uterine homing of NK cells and up-regulates HLA-G gene expression, the ligand for various NK inhibitory receptors. At high concentrations, progesterone is a potent inducer of Th2-type cytokines as well as of LIF and M-CSF production by T cells. The possible mechanisms by which progesterone contributes to the maintenance of early and late pregnancy are discussed.
Julia Szekeres-Bartho; Jacek R Wilczynski; Pawel Basta; Jaroslaw Kalinka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-01-01
Journal Detail:
Title:  Frontiers in bioscience : a journal and virtual library     Volume:  13     ISSN:  1093-4715     ISO Abbreviation:  Front. Biosci.     Publication Date:  2008  
Date Detail:
Created Date:  2007-11-05     Completed Date:  2007-12-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9709506     Medline TA:  Front Biosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1981-90     Citation Subset:  IM    
Department of Medical Microbiology and Immunology, Medical School, Pecs University, H-7643 Pecs, Hungary.
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MeSH Terms
Abortion, Threatened / metabolism*
Cytokines / metabolism
Killer Cells, Natural / metabolism
Monocytes / metabolism
Obstetric Labor, Premature / metabolism*
Oxidative Stress
Progesterone / metabolism,  physiology*
Progestins / therapeutic use*
Prostaglandins / metabolism
Reg. No./Substance:
0/Cytokines; 0/Progestins; 0/Prostaglandins; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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