Document Detail


Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases.
MedLine Citation:
PMID:  22024597     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Microglia are activated in response to a number of different pathological states within the CNS including injury, ischemia, and infection. Microglial activation results in their production of pro-inflammatory cytokines such as IL-1, IL-6, and TNF-α. While release of these factors is typically intended to prevent further damage to CNS tissue, they may also be toxic to neurons and other glial cells. Mounting evidence indicates that chronic microglial activation may also contribute to the development and progression of neurodegenerative disorders. Unfortunately, determining the role of pro-inflammatory cytokines in these disorders has been complicated by their dual roles in neuroprotection and neurodegeneration. The purpose of this review is to summarize current understanding of the involvement of cytokines in neurodegenerative disorders and their potential signaling mechanisms in this context. Taken together, recent findings suggest that microglial activation and pro-inflammatory cytokines merit interest as targets in the treatment of neurodegenerative disorders.
Authors:
Joshua A Smith; Arabinda Das; Swapan K Ray; Naren L Banik
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2011-10-18
Journal Detail:
Title:  Brain research bulletin     Volume:  87     ISSN:  1873-2747     ISO Abbreviation:  Brain Res. Bull.     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2011-12-26     Completed Date:  2012-05-17     Revised Date:  2014-04-30    
Medline Journal Info:
Nlm Unique ID:  7605818     Medline TA:  Brain Res Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  10-20     Citation Subset:  IM    
Copyright Information:
Published by Elsevier Inc.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytokines / immunology*
Humans
Inflammation / immunology*,  pathology
Microglia
Neurodegenerative Diseases / pathology*,  physiopathology*
Signal Transduction / physiology
Sympathetic Nervous System / physiology
Grant Support
ID/Acronym/Agency:
C06 RR015455/RR/NCRR NIH HHS; NS-31622/NS/NINDS NIH HHS; NS-38146/NS/NINDS NIH HHS; NS-41088/NS/NINDS NIH HHS; R01 NS031622/NS/NINDS NIH HHS; R01 NS038146/NS/NINDS NIH HHS; R01 NS041088/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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