| Role of pretreatment 18FDG-PET/CT in surgical decision-making for head and neck cancers. | |
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MedLine Citation:
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PMID: 20054849 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Despite widespread use, the utility of pretreatment positron emission tomography/computed tomography (PET/CT) remains undefined. In this study, we aim to determine its accuracy in nodal disease. METHODS: In all, 111 patients managed between 2003 and 2007 were analyzed. RESULTS: For squamous cell cancers (SCCs) with any increased nodal uptake (mild to high), sensitivity, specificity, positive predictive values (PPVs), and negative predictive values (NPVs) were 75%, 95%, 85%, and 90%. However, if PET was deemed positive for only moderate to high uptake, sensitivity, specificity, PPV, and NPV were 71%, 95%, 85%, and 89%. In patients undergoing elective neck dissection, the accuracy was lower: for any increased uptake, sensitivity, specificity, PPV, and NPV were 66%, 96%, 83%, and 92%, whereas for moderate to high uptake, these were 52%, 97%, 79%, and 89%. CONCLUSIONS: Despite advances in PET/CT technology, these statistics suggest that PET/CT is not sufficiently accurate to direct superselective neck dissections, or to guide therapeutic decisions in the N0 neck. |
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Authors:
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N Gopalakrishna Iyer; Jonathan R Clark; Shahlini Singham; Jacqui Zhu |
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Publication Detail:
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Type: Comparative Study; Evaluation Studies; Journal Article |
Journal Detail:
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Title: Head & neck Volume: 32 ISSN: 1097-0347 ISO Abbreviation: Head Neck Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-30 Completed Date: 2010-12-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8902541 Medline TA: Head Neck Country: United States |
Other Details:
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Languages: eng Pagination: 1202-8 Citation Subset: IM |
Affiliation:
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Sydney Head and Neck Cancer Institute, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, Australia. gopaliyer@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Biopsy, Needle Carcinoma, Squamous Cell / pathology, radionuclide imaging, surgery Cohort Studies Decision Making Female Fluorodeoxyglucose F18 / diagnostic use* Head and Neck Neoplasms / pathology, radionuclide imaging*, surgery* Humans Immunohistochemistry Lymph Node Excision Lymph Nodes / pathology* Male Middle Aged Neck Dissection / methods Neoplasm Staging / methods* Positron-Emission Tomography* Predictive Value of Tests Preoperative Care / methods Retrospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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