Document Detail

Role of premature translational termination in the regulation of expression of the phi X174 lysis gene.
MedLine Citation:
PMID:  2963134     Owner:  NLM     Status:  MEDLINE    
Expression of the phi X174 lysis (E) gene, a member of an overlapping gene pair, appears to depend on a frameshift-induced chain termination by ribosomes translating the upstream D gene. A -1 reading frameshift, possibly induced by misreading of an alanine codon as a doublet, causes ribosomes to terminate translation at two different sites, suggesting two modes of regulating expression of the E gene. One frameshift can cause translational termination at a stop codon(s) near the E gene ribosome binding site (RBS), resulting in reinitiation by ribosomes at the E gene RBS. Termination at a second site some 70 bases upstream from the E gene RBS, while too far away to allow ribosomal re-initiation at the E gene RBS, probably results in an unmasking of the message, allowing entry of a new ribosome at the E gene RBS.
K J Buckley; M Hayashi
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of molecular biology     Volume:  198     ISSN:  0022-2836     ISO Abbreviation:  J. Mol. Biol.     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-03-24     Completed Date:  1988-03-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  2985088R     Medline TA:  J Mol Biol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  599-607     Citation Subset:  IM    
Department of Biology, University of California, San Diego, La Jolla 92093.
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MeSH Terms
Bacteriophage phi X 174 / genetics*
Base Sequence
DNA, Viral
Gene Expression Regulation
Genes, Overlapping*
Genes, Regulator*
Genes, Viral*
Molecular Sequence Data
Protein Biosynthesis*
Terminator Regions, Genetic*
Grant Support
Reg. No./Substance:
0/DNA, Viral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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