| Role of premature translational termination in the regulation of expression of the phi X174 lysis gene. | |
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MedLine Citation:
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PMID: 2963134 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Expression of the phi X174 lysis (E) gene, a member of an overlapping gene pair, appears to depend on a frameshift-induced chain termination by ribosomes translating the upstream D gene. A -1 reading frameshift, possibly induced by misreading of an alanine codon as a doublet, causes ribosomes to terminate translation at two different sites, suggesting two modes of regulating expression of the E gene. One frameshift can cause translational termination at a stop codon(s) near the E gene ribosome binding site (RBS), resulting in reinitiation by ribosomes at the E gene RBS. Termination at a second site some 70 bases upstream from the E gene RBS, while too far away to allow ribosomal re-initiation at the E gene RBS, probably results in an unmasking of the message, allowing entry of a new ribosome at the E gene RBS. |
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Authors:
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K J Buckley; M Hayashi |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of molecular biology Volume: 198 ISSN: 0022-2836 ISO Abbreviation: J. Mol. Biol. Publication Date: 1987 Dec |
Date Detail:
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Created Date: 1988-03-24 Completed Date: 1988-03-24 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 2985088R Medline TA: J Mol Biol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 599-607 Citation Subset: IM |
Affiliation:
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Department of Biology, University of California, San Diego, La Jolla 92093. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/X07809 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Bacteriophage phi X 174
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genetics* Base Sequence DNA, Viral Gene Expression Regulation Genes* Genes, Overlapping* Genes, Regulator* Genes, Viral* Molecular Sequence Data Protein Biosynthesis* Terminator Regions, Genetic* |
| Grant Support | |
ID/Acronym/Agency:
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GM-12934/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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