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Role of preeclampsia-related angiogenic factors in sunitinib cardiotoxicity: two cases and review of the literature.
MedLine Citation:
PMID:  23252570     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Sunitinib is a multi-targeted tyrosine kinase inhibitor widely used in clear cell renal carcinoma and in imatinib-resistant gastrointestinal stromal tumors. Sunitinib-associated cardiotoxicity has been recognized and includes hypertension, left ventricular dysfunction and congestive heart failure; nevertheless, few data exist in the literature regarding the role of preeclampsia-related angiogenic factors in sunitinib cardiotoxicity. We report a case of sunitinib-induced severe left ventricular dysfunction that occurred in a hypertensive woman with metastatic renal carcinoma and a history of preeclampsia, and a case of sunitinib-induced preeclampsia-like syndrome in a normotensive patient with an imatinib-resistant gastrointestinal stromal tumor. Our experience confirms that inhibition of angiogenic factors to treat cancer is a novel challenge for the oncologist and requires the cardiologist's support.
Authors:
Giuseppina Gallucci; Alfredo Tartarone; Carlo Gabriele Tocchetti; Anna Maria Bochicchio; Mariarosa Coccaro; Alba Capobianco; Nicola Maurea; Giuseppina Improta; Angela Zupa; Michele Aieta
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Future oncology (London, England)     Volume:  9     ISSN:  1744-8301     ISO Abbreviation:  Future Oncol     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101256629     Medline TA:  Future Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  127-33     Citation Subset:  IM    
Affiliation:
Cardiology Unit, Centro di Riferimento Oncologico di Basilicata IRCCS, Via Padre Pio 1, 85028 Rionero in Vulture (PZ), Italy. pina.gallucci@tiscali.it.
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