| Role of preeclampsia-related angiogenic factors in sunitinib cardiotoxicity: two cases and review of the literature. | |
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MedLine Citation:
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PMID: 23252570 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Sunitinib is a multi-targeted tyrosine kinase inhibitor widely used in clear cell renal carcinoma and in imatinib-resistant gastrointestinal stromal tumors. Sunitinib-associated cardiotoxicity has been recognized and includes hypertension, left ventricular dysfunction and congestive heart failure; nevertheless, few data exist in the literature regarding the role of preeclampsia-related angiogenic factors in sunitinib cardiotoxicity. We report a case of sunitinib-induced severe left ventricular dysfunction that occurred in a hypertensive woman with metastatic renal carcinoma and a history of preeclampsia, and a case of sunitinib-induced preeclampsia-like syndrome in a normotensive patient with an imatinib-resistant gastrointestinal stromal tumor. Our experience confirms that inhibition of angiogenic factors to treat cancer is a novel challenge for the oncologist and requires the cardiologist's support. |
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Authors:
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Giuseppina Gallucci; Alfredo Tartarone; Carlo Gabriele Tocchetti; Anna Maria Bochicchio; Mariarosa Coccaro; Alba Capobianco; Nicola Maurea; Giuseppina Improta; Angela Zupa; Michele Aieta |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Future oncology (London, England) Volume: 9 ISSN: 1744-8301 ISO Abbreviation: Future Oncol Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2012-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101256629 Medline TA: Future Oncol Country: England |
Other Details:
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Languages: eng Pagination: 127-33 Citation Subset: IM |
Affiliation:
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Cardiology Unit, Centro di Riferimento Oncologico di Basilicata IRCCS, Via Padre Pio 1, 85028 Rionero in Vulture (PZ), Italy. pina.gallucci@tiscali.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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