Document Detail

Role of potassium in the pathogenesis of hypertension.
MedLine Citation:
PMID:  8141160     Owner:  NLM     Status:  MEDLINE    
Epidemiologic studies from divergent geographic locations consistently demonstrate an inverse correlation between potassium intake and the prevalence of hypertension. Studies in experimental animals showed a varied blood pressure response to alterations in potassium intake. Spontaneously hypertensive rats and rats with renovascular hypertension manifest a hypotensive response to both potassium depletion and potassium supplementation. In contrast, potassium depletion induced by chronic mineralocorticoid administration is associated with an increase in blood pressure. Potassium supplementation in hypertensive subjects lowers blood pressure. Amelioration of diuretic-induced hypokalemia with potassium supplementation enhances the hypotensive effect of diuretics. Potassium depletion induced by dietary potassium restriction elevates blood pressure in normotensive and hypertensive subjects maintained on a normal sodium intake. Potassium depletion in humans is accompanied by sodium retention and calcium depletion. The hypertensive response to potassium depletion and the hypotensive response to potassium supplementation do not manifest if sodium intake is kept low. Sodium retention, altered response to vasoactive hormones, direct vasoconstrictive effects of hypokalemia, and calcium depletion may all contribute to blood pressure elevation during potassium depletion.
G G Krishna
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of the medical sciences     Volume:  307 Suppl 1     ISSN:  0002-9629     ISO Abbreviation:  Am. J. Med. Sci.     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-04-28     Completed Date:  1994-04-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370506     Medline TA:  Am J Med Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S21-5     Citation Subset:  AIM; IM    
Renal Electrolyte Section, University of Pennsylvania, Philadelphia 19104-6144.
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MeSH Terms
Calcium / metabolism
Hypertension / etiology*
Potassium / administration & dosage*
Renin / blood
Sodium / metabolism
Reg. No./Substance:
7440-09-7/Potassium; 7440-23-5/Sodium; 7440-70-2/Calcium; EC

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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