| Role of polyamines in hypertension induced by angiotensin II. | |
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MedLine Citation:
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PMID: 7895239 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension. METHODS: Rats were chronically infused with a low dose of angiotensin II (83 ng.min-1.rat-1) or vehicle by osmotic minipumps. The polyamine content of the cardiovascular organs and liver was measured by HPLC, and the blood pressure of conscious rats was determined by a tail cuff method. The mesenteric arterial beds were perfusion fixed in situ and medial and luminal cross sectional areas were determined by computer assisted planimetry. Cardiac hypertrophy was assessed by determination of ventricular:body weight ratios. RESULTS: Angiotensin II infusion caused an increased concentration of polyamines in the ventricles and aorta within hours of beginning the infusion, and within days in the mesenteric arteries. Polyamine content of the liver was unaffected. Hypertrophy of the myocardium and mesenteric arteries in association with the increased blood pressure was evident. CONCLUSIONS: A low dose of angiotensin II stimulates an early biochemical marker of growth, the polyamines, in cardiovascular tissues but not in the liver. The increase in tissue polyamines is associated with cardiovascular hypertrophy and the development of hypertension. |
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Authors:
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J Ibrahim; M Schachter; A D Hughes; P S Sever |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cardiovascular research Volume: 29 ISSN: 0008-6363 ISO Abbreviation: Cardiovasc. Res. Publication Date: 1995 Jan |
Date Detail:
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Created Date: 1995-04-21 Completed Date: 1995-04-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0077427 Medline TA: Cardiovasc Res Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 50-6 Citation Subset: IM |
Affiliation:
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Department of Clinical Pharmacology, St Mary's Hospital Medical School, London, United Kingdom. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin II
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pharmacology* Animals Aorta / chemistry Cardiomegaly / metabolism* Disease Models, Animal Heart Ventricles / chemistry Hypertension / metabolism* Liver / chemistry Male Mesenteric Arteries / metabolism Myocardium / chemistry, metabolism Polyamines / metabolism* Putrescine / analysis Rats Rats, Inbred WKY Spermidine / analysis Spermine / analysis |
| Chemical | |
Reg. No./Substance:
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0/Polyamines; 110-60-1/Putrescine; 11128-99-7/Angiotensin II; 124-20-9/Spermidine; 71-44-3/Spermine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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