Document Detail

Role of polyamines in hypertension induced by angiotensin II.
MedLine Citation:
PMID:  7895239     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim was to investigate the involvement of polyamines in the development of cardiovascular hypertrophy in a rat angiotensin II infusion model of hypertension. METHODS: Rats were chronically infused with a low dose of angiotensin II (83 ng.min-1.rat-1) or vehicle by osmotic minipumps. The polyamine content of the cardiovascular organs and liver was measured by HPLC, and the blood pressure of conscious rats was determined by a tail cuff method. The mesenteric arterial beds were perfusion fixed in situ and medial and luminal cross sectional areas were determined by computer assisted planimetry. Cardiac hypertrophy was assessed by determination of ventricular:body weight ratios. RESULTS: Angiotensin II infusion caused an increased concentration of polyamines in the ventricles and aorta within hours of beginning the infusion, and within days in the mesenteric arteries. Polyamine content of the liver was unaffected. Hypertrophy of the myocardium and mesenteric arteries in association with the increased blood pressure was evident. CONCLUSIONS: A low dose of angiotensin II stimulates an early biochemical marker of growth, the polyamines, in cardiovascular tissues but not in the liver. The increase in tissue polyamines is associated with cardiovascular hypertrophy and the development of hypertension.
J Ibrahim; M Schachter; A D Hughes; P S Sever
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cardiovascular research     Volume:  29     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1995 Jan 
Date Detail:
Created Date:  1995-04-21     Completed Date:  1995-04-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  50-6     Citation Subset:  IM    
Department of Clinical Pharmacology, St Mary's Hospital Medical School, London, United Kingdom.
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MeSH Terms
Angiotensin II / pharmacology*
Aorta / chemistry
Cardiomegaly / metabolism*
Disease Models, Animal
Heart Ventricles / chemistry
Hypertension / metabolism*
Liver / chemistry
Mesenteric Arteries / metabolism
Myocardium / chemistry,  metabolism
Polyamines / metabolism*
Putrescine / analysis
Rats, Inbred WKY
Spermidine / analysis
Spermine / analysis
Reg. No./Substance:
0/Polyamines; 110-60-1/Putrescine; 11128-99-7/Angiotensin II; 124-20-9/Spermidine; 71-44-3/Spermine

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