Document Detail

Role of polyamines in gastrointestinal mucosal growth.
MedLine Citation:
PMID:  2058669     Owner:  NLM     Status:  MEDLINE    
The polyamines have been under active investigation for nearly three decades. There is a great deal of evidence that they play an important role in gastrointestinal mucosal growth, but the mechanisms through which this role is carried out are still not fully explained. This review examines the role of the polyamines in the regulation of mucosal growth, the control of intracellular polyamine levels, the biosynthesis of the polyamines, and some known mechanisms of their action. Finally, we propose a model of polyamine action that reconciles the effects of various trophic agents and situations in which growth is stimulated along with concomitant changes in polyamine levels. It accounts for both humoral and gradient-oriented features of various adaptive responses of the gastrointestinal mucosa and is intended to provide a framework for the future investigation of the role of the polyamines in this tissue.
S A McCormack; L R Johnson
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Publication Detail:
Type:  Editorial; Review    
Journal Detail:
Title:  The American journal of physiology     Volume:  260     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1991 Jun 
Date Detail:
Created Date:  1991-07-30     Completed Date:  1991-07-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  G795-806     Citation Subset:  IM    
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MeSH Terms
Cell Division
Gastric Mucosa / cytology*
Intestinal Mucosa / cytology*
Models, Biological
Polyamines / metabolism*
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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