| Role of platelets and serine proteinases in coupling of blood coagulation and inflammation. | |
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MedLine Citation:
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PMID: 15527406 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In addition to having a key role in thrombogenesis, platelets are actively involved in acute and chronic inflammation: they induce the release of proinflammatory mediators, expose adhesion molecules, and recruit leukocytes. The inflammation-induced expression of tissue factor by endothelium and monocytes leads to production of hemostatic serine proteinases, which can regulate both blood coagulation and the inflammatory response of the body. Serine proteinases activate blood and connective tissue cells and regulate blood coagulation, inflammation, tissue repair, atherogenesis, etc. This review considers new functions of platelets in thrombogenesis and inflammation, stabilization of platelet-platelet and platelet-leukocyte aggregations, receptor functions of tissue factor, proinflammatory properties of hemostatic serine proteinases mediated by proteinase-activated receptors (PAR), activation of transcriptional factors (NFkappaB and other), and antiinflammatory and cytoprotective properties of the anticoagulant proteinase (activated protein C) mediated through binding of the endothelial protein C receptor (EPCR) and cleavage of PAR1. |
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Authors:
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S M Strukova |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Biochemistry. Biokhimii͡a Volume: 69 ISSN: 0006-2979 ISO Abbreviation: Biochemistry Mosc. Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-11-05 Completed Date: 2005-04-25 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376536 Medline TA: Biochemistry (Mosc) Country: United States |
Other Details:
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Languages: eng Pagination: 1067-81 Citation Subset: IM |
Affiliation:
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Faculty of Biology, Lomonosov Moscow State University, Moscow 119992, Russia. strukova@mail.ru |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Blood Coagulation
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physiology* Blood Platelets / metabolism* Cell Adhesion / physiology Cell Adhesion Molecules / physiology Inflammation / enzymology, metabolism* Integrins / physiology P-Selectin / physiology Receptors, Collagen / physiology Serine Endopeptidases / physiology* von Willebrand Factor / physiology |
| Chemical | |
Reg. No./Substance:
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0/Cell Adhesion Molecules; 0/Integrins; 0/P-Selectin; 0/Receptors, Collagen; 0/von Willebrand Factor; EC 3.4.21.-/Serine Endopeptidases |
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