Document Detail


Role of platelets and lymphocytes for the hemodynamic effects of rapidly injected antilymphocyte globulin.
MedLine Citation:
PMID:  631148     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Xenogenic antilymphocyte globulin (ALG) given as a rapid intravenous injection into dogs caused a significant decrease in arterial blood pressure and oxygenation as well as an increase in portal pressure. At the same time, there was an almost complete elimination of lymphocytes and an extensive but almost completely reversible thrombocytopenia. Lymphocytopenia induced by a previous injection of ALG was found to eliminate completely the circulatory response to a second injection of ALG in spite of the fact that an extensive thrombocytopenia was induced. Extensive thrombocytopenia induced by injection of an antiplatelet globulin was also found to prevent completely the hemodynamic effects of ALG although as many lymphocytes were eliminated as in the intact dogs. Thus both platelets and lymphocytes are necessary to trigger the circulatory response induced by ALG.
Authors:
A Henricsson; S E Bergentz
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European surgical research. Europäische chirurgische Forschung. Recherches chirurgicales européennes     Volume:  10     ISSN:  0014-312X     ISO Abbreviation:  Eur Surg Res     Publication Date:  1978  
Date Detail:
Created Date:  1978-05-08     Completed Date:  1978-05-08     Revised Date:  2006-11-30    
Medline Journal Info:
Nlm Unique ID:  0174752     Medline TA:  Eur Surg Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  40-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anaphylaxis
Animals
Antilymphocyte Serum / administration & dosage*
Blood Platelets / immunology*
Blood Pressure*
Dogs
Injections, Intravenous
Leukopenia / etiology
Lymphocytes / immunology*
Neutrophils / immunology
Thrombocytopenia / etiology
Chemical
Reg. No./Substance:
0/Antilymphocyte Serum

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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