Document Detail

Role of platelet cytosolic calcium in regulation of blood pressure in patients on chronic hemodialysis.
MedLine Citation:
PMID:  1501742     Owner:  NLM     Status:  MEDLINE    
We measured blood pressure, platelet cytosolic calcium concentration ([Ca2+]i) and vasoactive hormones in 20 anuric normotensive patients on chronic hemodialysis (HD) to clarify the role of cytosolic calcium in regulation of blood pressure. All measurements were performed at the end of HD (post-HD) and at the beginning of the next HD (pre-HD). During the HD-HD interval, mean blood pressure increased from 85 +/- 4 to 94 +/- 4 mm Hg (mean +/- SEM, p less than 0.05), but the median [Ca2+]i in platelets did not show any significant change (133 +/- 5 vs. 136 +/- 5 nmol/l). Although all patients were within their ideal body weight at post-HD, platelet [Ca2+]i did not correlate with mean blood pressure. By contrast, platelet [Ca2+]i correlated with mean blood pressure (r = 0.489, p less than 0.05) at pre-HD. Moreover, platelet [Ca2+]i at post-HD also correlated with changes in mean blood pressure during the HD-HD interval (r = 0.532, p less than 0.05). In addition, there were negative correlations between platelet [Ca2+]i and plasma renin activity both post- and pre-HD (r = -0.652, p less than 0.005; r = -0.673, p less than 0.005; respectively). These results suggest that cytosolic calcium plays important roles in regulation of renin secretion and in the elevation of blood pressure induced by volume expansion in patients on chronic HD.
M Nakamura; H Suzuki; H Yamakawa; T Saruta
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nephron     Volume:  61     ISSN:  0028-2766     ISO Abbreviation:  Nephron     Publication Date:  1992  
Date Detail:
Created Date:  1992-09-11     Completed Date:  1992-09-11     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0331777     Medline TA:  Nephron     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  435-41     Citation Subset:  IM    
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan.
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MeSH Terms
Blood Platelets / metabolism*
Blood Pressure / physiology*
Calcium / metabolism*
Cytosol / metabolism
Hypertension / blood,  etiology
Kidney Failure, Chronic / blood,  physiopathology,  therapy
Middle Aged
Renal Dialysis* / adverse effects
Renin / secretion
Reg. No./Substance:
7440-70-2/Calcium; EC

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