| Role of plasma and urinary calcium and phosphorus measurements in early detection of phosphorus deficiency in very low birthweight infants. | |
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MedLine Citation:
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PMID: 12650304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To analyse the role of serum and urinary calcium and phosphorus levels in early detection of mineral deficiency in very low birthweight (VLBW) infants born appropriate (AGA) and small for gestational age (SGA). METHODS: 64 VLBW infants were included in a cohort study and divided into two groups: AGA (n = 30) and SGA infants (n = 34). Then, they were divided according to the presence of radiological signs of metabolic bone disease (MBD): with MBD (n = 21) and without MBD (n = 34). Blood samples and 6 h urine collections were obtained for calcium, phosphorus, alkaline phosphatase activity and creatinine determinations between 3 and 5 wk of life. RESULTS: There were no biochemical differences between AGA and SGA. Higher values of urinary calcium (MBD = 31.9 +/- 20.2, without MBD = 19.8 +/- 15.4; p = 0.017), calciuria (MBD = 2.3 +/- 0.3, without MBD = 1.4 +/- 0.8; p = 0.037) and alkaline phosphatase activity (MBD = 369 +/- 114, without MBD = 310 +/- 93; p = 0.04) were found in infants who developed MBD. Both groups showed high tubular phosphorus reabsorption indicating mineral deficiency. CONCLUSION: Serum calcium and phosphorus levels are not good markers in early detection of mineral deficiency. However, the monitoring of calcium urinary levels may be helpful in early detection of mineral deficiency. |
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Authors:
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M Catache; C R Leone |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta paediatrica (Oslo, Norway : 1992) Volume: 92 ISSN: 0803-5253 ISO Abbreviation: Acta Paediatr. Publication Date: 2003 |
Date Detail:
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Created Date: 2003-03-24 Completed Date: 2003-06-19 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9205968 Medline TA: Acta Paediatr Country: Norway |
Other Details:
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Languages: eng Pagination: 76-80 Citation Subset: IM |
Affiliation:
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Department of Pediatrics, Nursery Annex to Maternity Ward, Children's Institute, Clinics Hospital, School of Medicine University of São Paulo, SP, Brazil. bmancini@terra.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alkaline Phosphatase
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blood,
urine Bone Diseases, Metabolic / etiology Calcium / blood*, urine* Cohort Studies Creatine / blood, urine Humans Hypophosphatemia / blood*, complications, urine* Infant, Newborn Infant, Premature Infant, Very Low Birth Weight Phosphorus / blood*, urine* Prospective Studies |
| Chemical | |
Reg. No./Substance:
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57-00-1/Creatine; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC 3.1.3.1/Alkaline Phosphatase |
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