Document Detail

Role of plasma and urinary calcium and phosphorus measurements in early detection of phosphorus deficiency in very low birthweight infants.
MedLine Citation:
PMID:  12650304     Owner:  NLM     Status:  MEDLINE    
AIM: To analyse the role of serum and urinary calcium and phosphorus levels in early detection of mineral deficiency in very low birthweight (VLBW) infants born appropriate (AGA) and small for gestational age (SGA). METHODS: 64 VLBW infants were included in a cohort study and divided into two groups: AGA (n = 30) and SGA infants (n = 34). Then, they were divided according to the presence of radiological signs of metabolic bone disease (MBD): with MBD (n = 21) and without MBD (n = 34). Blood samples and 6 h urine collections were obtained for calcium, phosphorus, alkaline phosphatase activity and creatinine determinations between 3 and 5 wk of life. RESULTS: There were no biochemical differences between AGA and SGA. Higher values of urinary calcium (MBD = 31.9 +/- 20.2, without MBD = 19.8 +/- 15.4; p = 0.017), calciuria (MBD = 2.3 +/- 0.3, without MBD = 1.4 +/- 0.8; p = 0.037) and alkaline phosphatase activity (MBD = 369 +/- 114, without MBD = 310 +/- 93; p = 0.04) were found in infants who developed MBD. Both groups showed high tubular phosphorus reabsorption indicating mineral deficiency. CONCLUSION: Serum calcium and phosphorus levels are not good markers in early detection of mineral deficiency. However, the monitoring of calcium urinary levels may be helpful in early detection of mineral deficiency.
M Catache; C R Leone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  92     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2003  
Date Detail:
Created Date:  2003-03-24     Completed Date:  2003-06-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  76-80     Citation Subset:  IM    
Department of Pediatrics, Nursery Annex to Maternity Ward, Children's Institute, Clinics Hospital, School of Medicine University of São Paulo, SP, Brazil.
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MeSH Terms
Alkaline Phosphatase / blood,  urine
Bone Diseases, Metabolic / etiology
Calcium / blood*,  urine*
Cohort Studies
Creatine / blood,  urine
Hypophosphatemia / blood*,  complications,  urine*
Infant, Newborn
Infant, Premature
Infant, Very Low Birth Weight
Phosphorus / blood*,  urine*
Prospective Studies
Reg. No./Substance:
57-00-1/Creatine; 7440-70-2/Calcium; 7723-14-0/Phosphorus; EC Phosphatase

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