Document Detail

Role of plaque rupture in acute coronary syndromes.
MedLine Citation:
PMID:  11081445     Owner:  NLM     Status:  MEDLINE    
Acute coronary syndromes are caused by plaque rupture. The conventional strategy of prevention of plaque rupture has been driven by the "lipid hypothesis"--if lipid levels are optimized to target levels, the risk of coronary events is decreased. Indeed, the hypothesis has been validated by the dramatic success of statin therapy. However, further major reductions in cardiac events is a realistic goal; various mechanistic and small clinical studies show that statins have beneficial effects in addition to their lipid-lowering properties. One of these beneficial effects is stabilization of plaque. Despite billions of dollars spent on randomized clinical trials, optimal therapy for coronary artery disease is yet to be tested. This therapy might include various combinations of the Mediterranean or low-fat diet, endothelial passivation, lipid-lowering drugs, antioxidants, antiplatelet agents and anti-inflammatory agents.
J S Forrester
Related Documents :
9625405 - Effective lipid modification by partial ileal bypass reduced long-term coronary heart d...
15695135 - Effect of statin therapy on risk of ventricular arrhythmia among patients with coronary...
2395495 - Homozygous familial hypercholesterolaemia: metabolic studies and treatment with ldl aph...
11448415 - Measurement of plasma lipids in patients admitted with acute myocardial infarction or u...
10090345 - Reduction of myocardial infarct size by inhibition of inducible nitric oxide synthase.
9237415 - Recurrent branch retinal infarcts in association with migraine.
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The American journal of cardiology     Volume:  86     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-16     Completed Date:  2000-11-21     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  15J-23J     Citation Subset:  AIM; IM    
Division of Cardiology, Cedars-Sinai Medical Center, and the University of California Los Angeles School of Medicine, 90048, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Antilipemic Agents / therapeutic use*
Coronary Disease / drug therapy,  metabolism*,  pathology,  physiopathology
Rupture, Spontaneous
Reg. No./Substance:
0/Antilipemic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Relation between endothelial dysfunction and the acute coronary syndrome: implications for therapy.
Next Document:  Medical therapy of unstable angina and non-Q-wave myocardial infarction.