Document Detail

Role of peripheral serotonin in the regulation of central sleep apneas in rats.
MedLine Citation:
PMID:  10334159     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: The aim of our study was to determine the effects of serotonin (5-HT), which does not penetrate the blood-brain barrier (BBB), and GR38032F, a 5-HT3 receptor antagonist that may cross the BBB, on spontaneous apneas in adult Sprague-Dawley rats. MEASUREMENTS AND RESULTS: Rats were implanted with electrodes for EEG and electromyographic recording to monitor sleep, with a radiotelemetry transmitter for monitoring aortic BP and heart period (HP) and were placed inside a single chamber plethysmograph for monitoring respiration. Sleep, BP, HP, and respiration were monitored for 6 h following administration of drugs. Intraperitoneal injection of 5-HT (0.79 mg/kg) to rats increased spontaneous central apneas during rapid eye movement (REM) sleep by > 250% in comparison to control recording (p = 0.01). GR38032F (0.1 mg/kg), which produced no effect on apnea expression, completely blocked the 5-HT-induced increase in REM apneas. Administration of 5-HT did not affect apnea expression in non-REM sleep and had no effect on sleep or BP. CONCLUSIONS: From these observations, we conclude that binding at 5-HT3 receptors in the peripheral nervous system promotes REM-related apnea genesis in rats. These findings further suggest that endogenous 5-HT, acting at least at peripheral 5-HT3 receptors, may play a baseline physiologic role in the expression of spontaneous central apneas in rats.
D W Carley; M Radulovacki
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Chest     Volume:  115     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-14     Completed Date:  1999-06-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1397-401     Citation Subset:  AIM; IM    
Department of Medicine, University of Illinois College of Medicine at Chicago, 60612, USA.
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MeSH Terms
Ondansetron / pharmacology
Peripheral Nervous System / metabolism
Rats, Sprague-Dawley
Receptors, Serotonin / metabolism
Serotonin / metabolism,  physiology*
Serotonin Antagonists / pharmacology
Sleep Apnea Syndromes / physiopathology*
Sleep Stages
Grant Support
Reg. No./Substance:
0/Receptors, Serotonin; 0/Serotonin Antagonists; 50-67-9/Serotonin; 99614-02-5/Ondansetron

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