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Role of pentoxifylline in treatment of anemic patients suffering chronic hemodialysis: a randomized clinical trial.
MedLine Citation:
PMID:  22486134     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
BACKGROUND: Anemia is a major problem in patients with end-stage renal disease on chronic hemodialysis. rh-EPO is used mostly to elevate serum hemoglobin level and improve complaints caused by anemia, although in some patients it may not be totally effective for treating the disease. In this study, we aimed to evaluate pentoxifylline as a drug for treating anemia.
METHODS AND MATERIAL: Fifty patients were enrolled in the study and divided into 2 groups. The case group took 400 mg of pentoxifylline daily for 6 months, while the control group took placebo for the same time. The levels of hemoglobin and serum albumin, TIBC, iron, ferritin, and PTH, and use of rh-EPO were estimated. The data were analyzed using SPSS-18 software.
RESULTS: Of the 50 patients, 33 (66%) were male and 17 (34%) were female. Student paired t tests showed no significant difference in hemoglobin and serum albumin, TIBC, ferritin, and PTH levels, or use of rh-EPO between the case and control groups. However, iron level was significantly different in the 2 groups.
CONCLUSION: In contrast to previous studies, our data do not support the concept that pentoxifylline elevates hemoglobin level and improves anemia, Further studies on a larger number of patients are required to assess whether or not pentoxifylline is useful in these patients.
Authors:
Mojgan Mortazavi; Shiva Seyrafian; Shahram Taheri; Rezvan Nasiri; Shahaboddin Dolatkhah; Afsoon Emami Naini; Abolamir Atapour
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medicinski arhiv     Volume:  66     ISSN:  0350-199X     ISO Abbreviation:  Med Arh     Publication Date:  2012  
Date Detail:
Created Date:  2012-04-10     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0400722     Medline TA:  Med Arh     Country:  Bosnia and Hercegovina    
Other Details:
Languages:  eng     Pagination:  84-6     Citation Subset:  IM    
Affiliation:
Isfahan Kidney Diseases Research Center, Department of Nephrology, Isfahan University of Medical Sciences, Isfahan, Iran.
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